CAJ | 학술논문

目的探讨超氧化物歧化酶(SOD)在肺癌发病过程中的作用.方法采用黄嘌呤氧化酶法检测30例正常人及29例肺癌患者化疗前及化疗1、2、3个周期后血浆SOD值,并进行对比研究.结果肺癌组血浆SOD明显低于对照组(P＜0.01),化疗1、2个周期后SOD升高,但仍低于对照组(P＜0.01),化疗3个周期后SOD与对照组比较差异无统计学意义(P＞0.05),化疗前后鳞癌与腺癌间SOD值差异无统计学意义(P＞0.05),腺癌、鳞癌与鳞腺癌间SOD差异有统计学意义(P＜0.01).各周期化疗后SOD差异有统计学意义(P＜0.01).结论 SOD与肺癌的发生、发展、治疗有关,可作为肺癌诊治的一个临床检测及疗效判定的指标.
목적 탐토초양화물기화매(SOD)재폐암발병과정중적작용.방법 채용황표령양화매법검측30례정상인급29례폐암환자화료전급화료1、2、3개주기후혈장SOD치,병진행대비연구.결과 폐암조혈장SOD명현저우대조조(P＜0.01),화료1、2개주기후SOD승고,단잉저우대조조(P＜0.01),화료3개주기후SOD여대조조비교차이무통계학의의(P＞0.05),화료전후린암여선암간SOD치차이무통계학의의(P＞0.05),선암、린암여린선암간SOD차이유통계학의의(P＜0.01).각주기화료후SOD차이유통계학의의(P＜0.01).결론 SOD여폐암적발생、발전、치료유관,가작위폐암진치적일개림상검측급료효판정적지표.
Objective To detect the level of plasma superoxide dismutase(SOD) in patients with lung cancer and effect of chemotherapy(CGM + CBP) on it,and to investigate the role of SOD in the development .of lung cancer. Methods Xanthine oxidation enzyme was availabe to detect the level of plasma SOD in 30 cases of normal control subjects and 29 cases of patients with lung cancer before and after first, second, third cycle of chemotherapy. Resuits The levels of plasma SOD in lung cancer after chemotherapy were lower than those in the control group(P＜0.01). The level of plasma SOD in lung cancer after first and second chemo-cycle was higher than that before, but lower than that of control group(P＜0.01), the differences between after third chemo-cycle and control group were not significant(P＞0.05 ). The differences in squamoun cell carcinoma and adenocarcinoma before chemothrapy and after were not significant (P＞0.05 ). The differences in squamoun cell carcinoma and adenocarcinoma and adenosquamoun carcinoma before chemotherapy and after were highly significant (P＜0.01 ). The differences in each chemo-cycle were highly significant (P＜0.01). Conclusion SOD played an important role in growth, regulation and treatment of lung cancer,and it might be a clinical index in lung cancer.