中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2009年
1期
34-35
,共2页
丝裂霉素C%胬肉%自体角膜缘干细胞移植
絲裂黴素C%胬肉%自體角膜緣榦細胞移植
사렬매소C%노육%자체각막연간세포이식
Pterygium%MMC%limbal stem cell autografling
目的 丝裂霉素C能抑制翼状胬肉切除术后的复发,研究胬肉切除术中应用丝裂霉素C治疗翼状胬肉的有效性和安全性.方法 将原发性翼状胬肉患者随机分为三组,术中应用0.02%丝裂霉素C组、术后用0.02%丝裂霉素C组和胬肉切除加角膜缘干细胞移植术组,观察术后复发率和并发症情况.结果 共有132例153只眼纳入本研究,其中术中用丝裂霉素C组50只眼中3只眼复发(6.0%),术后用丝裂霉素C组51只眼中4只眼复发(7.5%),胬肉切除加角膜缘干细胞移植术组52只眼中3只眼复发(5.8%).三组间差别无统计学意义(P>0.05);随访期间三组患者均没有出现严重的并发症.结论 翼状胬肉切除术中应用丝裂霉素C是治疗翼状胬肉简易有效地方法,且较术后应用丝裂霉素C可能更为安全.
目的 絲裂黴素C能抑製翼狀胬肉切除術後的複髮,研究胬肉切除術中應用絲裂黴素C治療翼狀胬肉的有效性和安全性.方法 將原髮性翼狀胬肉患者隨機分為三組,術中應用0.02%絲裂黴素C組、術後用0.02%絲裂黴素C組和胬肉切除加角膜緣榦細胞移植術組,觀察術後複髮率和併髮癥情況.結果 共有132例153隻眼納入本研究,其中術中用絲裂黴素C組50隻眼中3隻眼複髮(6.0%),術後用絲裂黴素C組51隻眼中4隻眼複髮(7.5%),胬肉切除加角膜緣榦細胞移植術組52隻眼中3隻眼複髮(5.8%).三組間差彆無統計學意義(P>0.05);隨訪期間三組患者均沒有齣現嚴重的併髮癥.結論 翼狀胬肉切除術中應用絲裂黴素C是治療翼狀胬肉簡易有效地方法,且較術後應用絲裂黴素C可能更為安全.
목적 사렬매소C능억제익상노육절제술후적복발,연구노육절제술중응용사렬매소C치료익상노육적유효성화안전성.방법 장원발성익상노육환자수궤분위삼조,술중응용0.02%사렬매소C조、술후용0.02%사렬매소C조화노육절제가각막연간세포이식술조,관찰술후복발솔화병발증정황.결과 공유132례153지안납입본연구,기중술중용사렬매소C조50지안중3지안복발(6.0%),술후용사렬매소C조51지안중4지안복발(7.5%),노육절제가각막연간세포이식술조52지안중3지안복발(5.8%).삼조간차별무통계학의의(P>0.05);수방기간삼조환자균몰유출현엄중적병발증.결론 익상노육절제술중응용사렬매소C시치료익상노육간역유효지방법,차교술후응용사렬매소C가능경위안전.
Objective Aim This study was conducted to examine the efficacy and safety of intmopera-tire MMC in preventing recurrence of pterygium.Methods Prospective study on consecutive cases of primary pterygium randomized into three adjuvant groups: (1)intraoperative 0.02% MMC for 5 minutes; (2)postopera-tive 0.02% MMC for 5 days; (3)pterygium excision followed by corneal limbal stem cell autografting (CLSCA).Patients were followed for recurrence and complications for a period of six months.Result 153 eyes of 132 patients who completed the study were randomized to receive intraoperative MMC (n=50), postop-erative MMC (n=51)or pterygium excision followed by CLSCA.There were 3 recurrences (6.0%)in the intra-operative group, 4 recurrences (7.5%)in the postoperative group and 3 recurrences (5.8%)in the pterygium ex-cision followed by CLSCA group.There was no statistically significant difference in the recurrence rate among the three groups (P>0.05 ).No significant complications were encountered in every group.Conclusion Simple excision combined with intraoperative MMC is effective and easy adjuvants for pterygium excision, but intra-operative MMC may be safer.Because of the possibility of serious late complications, controlled use of MMC and long term follow up are required.
