CAJ | 학술논문

目的探讨哈萨克族妇女妊娠分娩前后易发深静脉血栓的抗凝方面的因素.方法检测哈萨克族妇女36例、汉族妇女39例分娩前后的蛋白C、蛋白S、抗凝血酶Ⅲ(AT-Ⅲ)活性、活化蛋白C抵抗比值(APCR).结果哈萨克族妇女分娩前后抗凝功能检测蛋白S(43.13±11.36,58.05±17.10)有显著性改变(P＜0.01),哈萨克族妇女分娩后抗凝功能检测值与汉族妇女分娩后比较,蛋白C(97.34±18.37,118.02±23.46)、蛋白S(58.05±17.10,67.97±19.22)差异有统计学意义(P＜0.05,其中蛋白C比较P＜0.01),但哈萨克族妇女分娩后抗凝指标均在正常范围内.结论正常妇女分娩前后存在血栓前状态,哈萨克族妇女亦存在明显的血栓前状态;蛋白C、蛋白S活性较汉族妇女低,可能是其分娩前后易发深静脉血栓的重要因素;分娩前后进行抗凝功能的检测对预防哈萨克族妇女深静脉血栓的形成有一定临床意义.
목적 탐토합살극족부녀임신분면전후역발심정맥혈전적항응방면적인소.방법 검측합살극족부녀36례、한족부녀39례분면전후적단백C、단백S、항응혈매Ⅲ(AT-Ⅲ)활성、활화단백C저항비치(APCR).결과 합살극족부녀분면전후항응공능검측단백S(43.13±11.36,58.05±17.10)유현저성개변(P＜0.01),합살극족부녀분면후항응공능검측치여한족부녀분면후비교,단백C(97.34±18.37,118.02±23.46)、단백S(58.05±17.10,67.97±19.22)차이유통계학의의(P＜0.05,기중단백C비교P＜0.01),단합살극족부녀분면후항응지표균재정상범위내.결론 정상부녀분면전후존재혈전전상태,합살극족부녀역존재명현적혈전전상태;단백C、단백S활성교한족부녀저,가능시기분면전후역발심정맥혈전적중요인소;분면전후진행항응공능적검측대예방합살극족부녀심정맥혈전적형성유일정림상의의.
Objective To investigate the anticoagulant factors that Kazakh women are prone to develop deep vein thrombosis before or after delivery.Methods The protein C,protein S,antithrombin Ⅲ (AT-Ⅲ) activity,activated protein C resistance ratio (APCR) of 36 Kazakh women cases and 39 Hans women cases before and after delivery were determined.Results The protein S (43.13±11.36,58.05±17.10) was significant changed (P＜0.01)in Kazakh women before and after delivery.The protein C (97.34±18.37,118.02±23.46) and protein S (58.05±17.10,67.97±19.22) were statistically different between Kazakh women and Han women after delivery(P＜0.05,which protein C was P＜0.01).The anticoagulant indexes of Kazak women after delivery was still within normal range.Conclusions Normal women have prothrombotic state before and after delivery,especially the Kazakh women.It may be an important factor of deep vein thrombosis-prone before and after delivery that protein C and protein S in Kazakh women have lower activity than that in Han women.The detection of anti-coagulation have some clinical significance on the prevention of the deep vein thrombosis in Kazakh women before and after delivery.