CAJ | 학술논문

目的观察埃索美拉唑治疗内蒙占地区不同民族胃食管反流病(GERD)患者的疗效.方法随机抽取2006年3月至2008年3月行胃镜检查及胃食管反流诊断问卷(RDQ)调查的120例汉族及120例蒙古族GERD患者,均给予埃索美拉唑20 mg每日1次口服,共6周.治疗2、4、6周时,以RDQ进行评分,RE患者治疗6周复查胃镜,观察胃镜下食管炎症愈合情况.结果两组口服埃索美拉唑2周后临床有效率均大于50%,但第4、6周时,蒙古族组有效率明显低于汉族组.6周后蒙古族RE患者愈合率明显低于汉族组.结论因民族差异、饮食习惯的不同,导致埃索美拉唑治疗效果的不同,可通过延长用药时间、调整饮食习惯来取得更好的疗效.
목적 관찰애색미랍서치료내몽점지구불동민족위식관반류병(GERD)환자적료효.방법 수궤추취2006년3월지2008년3월행위경검사급위식관반류진단문권(RDQ)조사적120례한족급120례몽고족GERD환자,균급여애색미랍서20 mg매일1차구복,공6주.치료2、4、6주시,이RDQ진행평분,RE환자치료6주복사위경,관찰위경하식관염증유합정황.결과 량조구복애색미랍서2주후림상유효솔균대우50%,단제4、6주시,몽고족조유효솔명현저우한족조.6주후몽고족RE환자유합솔명현저우한족조.결론 인민족차이、음식습관적불동,도치애색미랍서치료효과적불동,가통과연장용약시간、조정음식습관래취득경호적료효.
Objective To assess the therapeutic effect of esomerphrazole in treating patients with gastroesophageal reflux disease (GRED) between Han and Inner Mongolia populations.Methods Those who underwent endoscopic examination and had reflux disease questionnaire (RDQ) >12 from March 2006 to March 2008 were selected. The patients were divided into Han group and Inner Mongolia group with 120 each. All patients were received esomerphrazole 20 mg daily for 6 weeks. The patients were evaluated by RDQ questionnaire at 2nd, 4th and 6th week, and were reexamined by gastroscopy at 6th week. Results After two weeks, effective rate of 50% was achieved in both groups, but it was higher in Han group than in Inner Mongolia group at 4th and 6th week. After 6 weeks, the curative rate of RE was higher in Han group than in Inner Mongolia group. Conclusion The different nations ancl habits result in the different efficacy of esomerphrazole, which may be improved by prolonging time of medication and changing habits.