CAJ | 학술논문

目的观察口服胺碘酮联合应用血管紧张素Ⅱ受体拮抗剂(ARB)缬沙坦在阵发性心房颤动(简称房颤)复律后维持窦律的疗效及对左心房功能的影响.方法将68例阵发性房颤患者分为单纯口服胺碘酮组(对照组,34例)和胺碘酮加缬沙坦组(治疗组,34例),疗效观察12个月.结果共66例完成治疗,随访12个月,治疗1、3个月后两组左心房内径比较差异无统计学意义,但6、12个月后两组差异有统计学意义(P＜0.05),窦性心律维持6、12个月后比较差异有统计学意义(P＜0.05).结论胺碘酮与缬沙坦联合治疗阵发性房颤维持窦性心律的疗效优于单用胺碘酮,并能延缓左心房扩大.
목적 관찰구복알전동연합응용혈관긴장소Ⅱ수체길항제(ARB)힐사탄재진발성심방전동(간칭방전)복률후유지두률적료효급대좌심방공능적영향.방법 장68례진발성방전환자분위단순구복알전동조(대조조,34례)화알전동가힐사탄조(치료조,34례),료효관찰12개월.결과 공66례완성치료,수방12개월,치료1、3개월후량조좌심방내경비교차이무통계학의의,단6、12개월후량조차이유통계학의의(P＜0.05),두성심률유지6、12개월후비교차이유통계학의의(P＜0.05).결론 알전동여힐사탄연합치료진발성방전유지두성심률적료효우우단용알전동,병능연완좌심방확대.
Objective To investigate the efficacy of amiodarone combined with angiotensin Ⅱ receptor antagonist(ARB)valsartan on paroxysmal atrial fibrillation and left atrial function.Methods A total of 68 patients with paroxysmal atrial fibrillation were randomly divided into two groups:simple amiodarone group(control group,34 cases),amiodarone + valsartan group(stydy group,34 cases),they were treated for 12 months,following-up for 12 months.Results Totally 66 cases completed the treatment.The left atrium in simple amiodarone group was significantly higher than that in amiodarone + valsartan group 6-12 months after treatment(P ＜ 0.05); the maintenance rates of 6 months,12 months of sinus rhythm in amiodarone + valsartan group were significantly higher than those in simple amiodarone group(P ＜ 0.05).Conclusions Amiodarone combined with valsartan can reverse expansion of left atrium,and is more effective for transfer and maintain sinus rhythm compared with simple amiodarone treatment in patients with paroxysmal atrial fibrillation.