CAJ | 학술논문

目的观察脑米源神经生长因子(BDNF)对坐骨神经捻挫损伤后远端轴突再生的影响。方法采用病理学定性、定量分析技术对捻挫损伤的坐骨神经远端轴突进行分析。结果光镜下腓神经的大径纤维密度，实验组高于对照组(P＜0.01)，而小径纤维密度无差异电镜分析：直径0.5μm以下的无髓纤维密度对照组大于实验组。髓鞘层数和轴突横断面积二者之间为正相关(P＜0.01)。实验组的回归系数明显大于对照组(P=0.0023)。结论BDNF促进感觉神经纤维的成熟过程并对髓鞘形成有一定的促进作用。
목적관찰뇌미원신경생장인자(BDNF)대좌골신경념좌손상후원단축돌재생적영향。방법채용병이학정성、정량분석기술대념좌손상적좌골신경원단축돌진행분석。결과광경하비신경적대경섬유밀도，실험조고우대조조(P＜0.01)，이소경섬유밀도무차이전경분석：직경0.5μm이하적무수섬유밀도대조조대우실험조。수초층수화축돌횡단면적이자지간위정상관(P＜0.01)。실험조적회귀계수명현대우대조조(P=0.0023)。결론BDNF촉진감각신경섬유적성숙과정병대수초형성유일정적촉진작용。
Objective To explore the effect of brain derived neurotrophic factor(BDNF) on regeneration of distal axon in sciatic nerve after cfrush injury. Method Distal axon was assessed by quantitavtive and qualitative analysis of pathology Result Light microscope indicated thedensity of large diameter of peroneal-nerve was higher in study group compared with control group( P ＜0.01 ). No differences in density of littlediameter fiber were found between study and control group. EM showed the density of non-medullated fibers with diameter ＜0.5μm in studygroup was higher than that of control group. The numbers of layer in myelin was positively related to transverse axonal area( P ＜0.01 ) . The re-gression codfficient in study group wsa higher compared with control group( P = 0. 0023) . Conclusion BDNF may promoted maturation ofsensoy nerve and formation of the myeline.