CAJ | 학술논문

目的对矮地茶水提取物和醇提取物的抗炎、镇痛作用及急性毒性进行研究.方法采用二甲苯致小鼠耳廓肿胀法、醋酸扭体法观察矮地茶的抗炎、镇痛作用;对矮地茶水提物及醇提物的半数致死量(LD_(50))进行测定,观察其急性毒性.结果矮地茶对二甲苯所致小鼠耳肿胀有明显的抑制作用(P<0.01,P<0.05);对0.7%醋酸所致小鼠扭体反应有明显的抑制作用(P<0.01或P<0.05).矮地茶水提物及醇提物对小鼠灌胃给药的LD50分别为(115.77±10.31)g/kg, 95%可信限为(105.92～126.54)g/kg;(94.71±10.13)g/kg ,95%可信限为(85.12～105.38 )g/kg.结论矮地茶具有一定的抗炎、镇痛作用;矮地茶水提物及醇提取物未出现其它毒性反应.
목적 대왜지다수제취물화순제취물적항염、진통작용급급성독성진행연구.방법 채용이갑분치소서이곽종창법、작산뉴체법관찰왜지다적항염、진통작용;대왜지다수제물급순제물적반수치사량(LD_(50))진행측정,관찰기급성독성.결과 왜지다대이갑분소치소서이종창유명현적억제작용(P<0.01,P<0.05);대0.7%작산소치소서뉴체반응유명현적억제작용(P<0.01혹P<0.05).왜지다수제물급순제물대소서관위급약적LD50분별위(115.77±10.31)g/kg, 95%가신한위(105.92～126.54)g/kg;(94.71±10.13)g/kg ,95%가신한위(85.12～105.38 )g/kg.결론 왜지다구유일정적항염、진통작용;왜지다수제물급순제취물미출현기타독성반응.
Objective To study on the anti-inflammatory、analgesic and acute toxicity effects of the aqueous extract and alcohol extract of Aidicha.Methods The anti-inflammatory and analgesic effects of Aidicha were observed by means of dimethylbenzene inducing ear edema model, acetic acid writhing test. To observe acute toxicity with the aqueous extract of Aidicha and the alcohol extract of Aidicha by Lethal Dose 50(LD_(50)).Results Aidicha significantly inhibited the inflammation caused by xylene(P<0.01 or P<0.05) and inhibited writhing caused by 0.7% acetic acid (P<0.01 or P<0.05)in mice. The LD_(50) for acute toxicity of the aqueous extract and alcohol extract of Aidicha were 115.77±10.31g/kg(95%,105.92～126.54 g/kg);94.71±10.13g/kg (95%,85.12～105.38g/kg).Conclusion Aidicha has anti-inflammatory and analgesic effects. The aqueous extract and alcohol extract of Aidicha don' t have acute toxicity.