CAJ | 학술논문

背景:传统的供皮区创面修复以抗感染、支持及保护创面为主,最终为自然愈合,时间较长.研究表明,重组表皮生长因子促进皮肤切割、烧伤等动物模型创面的愈合,加速表皮再生的速度.目的:验证重组表皮生长因子对供皮区创面的修复效果.方法:选择泸州医学院附属医院整形烧伤科需要自体植皮修复创面的患者共32例,男18例,女14例.将32处新鲜供皮区创面随机均分为对照组和治疗组.治疗组将重组表皮生长因子药液(15 mL/支,2 000 IU/mL)直接喷洒于单层内敷纱布上直至浸透,然后覆盖到供皮区,2次/d;对照组将单层生理盐水纱布覆盖供皮区,外加敷料包扎,2次/d.48 h后,采用半暴露疗法.主要观察从治疗开始至供皮区完全愈合所需要的时间,不良事件及副反应,治疗前、后血常规及肝肾功能检测.结果与结论:在重组表皮生长因子喷洒组较生理盐水喷洒组明显缩短创面愈合时间,两组间比较具有显著差异(P<0.01).重组表皮生长因子喷洒组未见明显的不良事件及副反应发生.提示经重组人表皮细胞生长因子处理后,能明显缩短创面的愈合时间,减少了瘢痕的过度增生,在加速创面愈合及再上皮化中具有显著的促进作用.
배경:전통적공피구창면수복이항감염、지지급보호창면위주,최종위자연유합,시간교장.연구표명,중조표피생장인자촉진피부절할、소상등동물모형창면적유합,가속표피재생적속도.목적:험증중조표피생장인자대공피구창면적수복효과.방법:선택로주의학원부속의원정형소상과수요자체식피수복창면적환자공32례,남18례,녀14례.장32처신선공피구창면수궤균분위대조조화치료조.치료조장중조표피생장인자약액(15 mL/지,2 000 IU/mL)직접분쇄우단층내부사포상직지침투,연후복개도공피구,2차/d;대조조장단층생리염수사포복개공피구,외가부료포찰,2차/d.48 h후,채용반폭로요법.주요관찰종치료개시지공피구완전유합소수요적시간,불량사건급부반응,치료전、후혈상규급간신공능검측.결과여결론:재중조표피생장인자분쇄조교생리염수분쇄조명현축단창면유합시간,량조간비교구유현저차이(P<0.01).중조표피생장인자분쇄조미견명현적불량사건급부반응발생.제시경중조인표피세포생장인자처리후,능명현축단창면적유합시간,감소료반흔적과도증생,재가속창면유합급재상피화중구유현저적촉진작용.
BACKGROUND: The traditional treatment for skin donor site wound was focus on anti-infection and wound protection, which roof a long time for healing. Studies demonstrated that recombinant human epidermal growth factor (rhEGF) has accelerated effect or epidermal regeneration. OBJECTIVE: To observe the effect of rhEGF on wound healing of skin donor site. METHODS: A total of 32 cases needs wound healing by skin grafting were collected, including 18 males and 14 females. The 32 skin graft donor site wounds were randomly divided into control and treatment groups. In the treatment group, the absorbent gauze was sprinkle soaked with rhEGF (15 mL/ramus, 2 000 IU/mL) and covered the donor site, twice per day. In the control group, donor site was covered by physiological saline gauze and wrapped with dressing, twice per day. After 48 hours, semi-exposed therapy was performed. The healing time of wounds, the systemic and local adverse reactions of patients and blood routine examination and renal function detection prior to and after treatment were observed. RESULTS AND CONCLUSION: The healing time of wound in the rhEGF treatment group was shorter than that in the control group with significant differences (P < 0.01). No Adverse events or side effects were observed in the rhEGF treatment group. rhEGF can shorten wound healing time, reduce scar hyperplasia, and accelerate epithelization at the graft donor.