CAJ | 학술논문

背景:肺移植可以改善终末期肺病患者的生活质量同时延长生存期,目前已经成为终末期肺病最有效的治疗手段之一.然而肺源不足影响了肺移植的发展,活体肺叶移植以及尸体肺叶移植在一定程度上缓解了肺源不足.目的:评估双侧肺叶移植的临床可行性.方法:对1例26岁女性肺囊性纤维化受体进行序贯式双侧尸体肺叶移植,术中进行体外循环维持呼吸循环稳定,移植后给予抗排斥(他克莫司、霉酚酸酯)、抗感染(细菌、真菌)治疗.结果与结论:患者恢复过程较顺利,移植后恢复满意出院.提示双侧肺叶移植可以为肺囊性纤维化受体提供满意的近期肺功能,远期结果有待进一步评价.
배경:폐이식가이개선종말기폐병환자적생활질량동시연장생존기,목전이경성위종말기폐병최유효적치료수단지일.연이폐원불족영향료폐이식적발전,활체폐협이식이급시체폐협이식재일정정도상완해료폐원불족.목적:평고쌍측폐협이식적림상가행성.방법:대1례26세녀성폐낭성섬유화수체진행서관식쌍측시체폐협이식,술중진행체외순배유지호흡순배은정,이식후급여항배척(타극막사、매분산지)、항감염(세균、진균)치료.결과여결론:환자회복과정교순리,이식후회복만의출원.제시쌍측폐협이식가이위폐낭성섬유화수체제공만의적근기폐공능,원기결과유대진일보평개.
BACKGROUND: Lung transplantation can improve quality of life of patients who get terminal pulmonary disease and also it can help to get better survival.Now it has become one of the best therapeutic methods for terminal pulmonary disease.However,limited donors leave the development of lung transplantation in dilemma.The emergence of living lobar transplantation and cadeveric lobar transplantation let this procedure much easier.OBJECTIVE: To evaluate the clinical probability of bilateral lobar transplantation.METHODS: Sequential bilateral lobar transplantation was performed for one 26 years old cystic fibrosis female.Cardiac pulmonary bypass was used during operation.Anti-rejection(Tacrolimus,mycophenolate,etc)and anti-infection was used postoperatively.RESULTS AND CONCLUSION: The recovery course postoperatively was smooth,and the recipient got out of hospital 7weeks later.Bilateral lobar transplantation could offer satisfied short-term pulmonary function.The long term results should be further evaluated.