CAJ | 학술논문

E-cad基因启动子区CpG岛甲基化是消化道肿瘤中该基因失活的主要原因,可致E-cad表达下降或缺失,与食管癌、胃癌、肝细胞癌、胆管细胞癌、胆囊癌、胰腺癌及结直肠癌等多种消化道肿瘤的发生、发展、浸润转移和预后密切相关.E-cad基因甲基化的进一步研究将有可能指导消化道肿瘤的早期诊断、基因治疗、预防及预测肿瘤转移复发等.
E-cad기인계동자구CpG도갑기화시소화도종류중해기인실활적주요원인,가치E-cad표체하강혹결실,여식관암、위암、간세포암、담관세포암、담낭암、이선암급결직장암등다충소화도종류적발생、발전、침윤전이화예후밀절상관.E-cad기인갑기화적진일보연구장유가능지도소화도종류적조기진단、기인치료、예방급예측종류전이복발등.
The methylation of CpG island in promoter region of E-cad gene which usually leads to inactivation of E-cad gene is closely related to the occurrence, development, invasion, metastasis and prognosis of a variety of gastrointestinal cancer, such as esophageal carcinoma, gastric carcinoma, hepatocellular carcinoma,cholangiocellular carcinoma, carcinoma of gallbladder, pancreatic carcinoma and colorectal cancer. Further study would probably guide the early diagnosis, gene therapy, prophylaxis and predicting recurrence of tumor metastasis of gastrointestinal cancer.