国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2010年
6期
340-342
,共3页
成骨细胞%剪切应力%细胞变形%力学转导
成骨細胞%剪切應力%細胞變形%力學轉導
성골세포%전절응력%세포변형%역학전도
Osteoblast%Shear stress%Cellular deformation%Mechanotransduction
目的 根据已有体外培养鼠成骨细胞的参数实验数据,估算剪切应力加载实验中细胞整体剪切形变,借以研究细胞的主要转导区域.方法 计算过程采用黏弹性力学理论,对细胞运用了标准黏弹性模型,并简化其膜所受剪切力为均匀.结果 细胞剪切力产生的细胞变形大约是引起成骨细胞相同生物学响应的拉伸加载变形的十分之一.结论 从细胞总的力学刺激生物学响应来看,剪切应力加载实验中细胞的整体变形所产生的力学转导是可以忽略的,主要转导区域在承受剪切应力的细胞膜.
目的 根據已有體外培養鼠成骨細胞的參數實驗數據,估算剪切應力加載實驗中細胞整體剪切形變,藉以研究細胞的主要轉導區域.方法 計算過程採用黏彈性力學理論,對細胞運用瞭標準黏彈性模型,併簡化其膜所受剪切力為均勻.結果 細胞剪切力產生的細胞變形大約是引起成骨細胞相同生物學響應的拉伸加載變形的十分之一.結論 從細胞總的力學刺激生物學響應來看,剪切應力加載實驗中細胞的整體變形所產生的力學轉導是可以忽略的,主要轉導區域在承受剪切應力的細胞膜.
목적 근거이유체외배양서성골세포적삼수실험수거,고산전절응력가재실험중세포정체전절형변,차이연구세포적주요전도구역.방법 계산과정채용점탄성역학이론,대세포운용료표준점탄성모형,병간화기막소수전절력위균균.결과 세포전절력산생적세포변형대약시인기성골세포상동생물학향응적랍신가재변형적십분지일.결론 종세포총적역학자격생물학향응래간,전절응력가재실험중세포적정체변형소산생적역학전도시가이홀략적,주요전도구역재승수전절응력적세포막.
Objective To study the main mechanotransduction area and to estimate the overall shear deformation of rat osteoblasts in shear stress loading experiment based on data acquired from the in vitro rat osteoblast experimental, and to study the effects of four-point bending medium flow generated shear stress on cells. Methods Viscoelastic mechanics theory was used in the calculation process, the standard viscoelastic model was adopted for cells, and shear force on the cellular surface was simplified to be uniform. Results The cellular deformation caused by shear force was about one-tenth of that from tensile loading experiment which induced equivalent biological response. Conclusion In terms of mechanical stimulus induced biological responds, the mechanical transduction caused by cellular deformation in shear stress loading experiment is negligible, and the main transduction area is in the cellular membranes experiencing shear stress.