中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2008年
11期
1-2
,共2页
黄辉%陈洁%王彤%王景峰%黄湖辉%徐安平
黃輝%陳潔%王彤%王景峰%黃湖輝%徐安平
황휘%진길%왕동%왕경봉%황호휘%서안평
妊娠%血流动力学%花生四烯酸%肾脏
妊娠%血流動力學%花生四烯痠%腎髒
임신%혈류동역학%화생사희산%신장
Pregnancy%Hemodynamics%Arachidonic acid%Kidney
目的 探讨肾脏微血管细胞色素P450表达与妊娠大鼠肾脏血流动力学变化的关系.方法 比较妊娠晚期与非妊娠大鼠肾脏血流动力学指标差异,运用Western blot和HPLC比较妊娠各个时期与非妊娠大鼠肾脏微血管细胞色素P450表达与活性.结果 与非妊娠大鼠相比,妊娠晚期大鼠平均动脉压和肾微血管阻力明显下降(P＜0.05),妊娠期CYP表达增加,产生EETs活性增加.结论 妊娠期肾脏血流动力学变化可能与肾脏微血管细胞色素P450表达有关.
目的 探討腎髒微血管細胞色素P450錶達與妊娠大鼠腎髒血流動力學變化的關繫.方法 比較妊娠晚期與非妊娠大鼠腎髒血流動力學指標差異,運用Western blot和HPLC比較妊娠各箇時期與非妊娠大鼠腎髒微血管細胞色素P450錶達與活性.結果 與非妊娠大鼠相比,妊娠晚期大鼠平均動脈壓和腎微血管阻力明顯下降(P＜0.05),妊娠期CYP錶達增加,產生EETs活性增加.結論 妊娠期腎髒血流動力學變化可能與腎髒微血管細胞色素P450錶達有關.
목적 탐토신장미혈관세포색소P450표체여임신대서신장혈류동역학변화적관계.방법 비교임신만기여비임신대서신장혈류동역학지표차이,운용Western blot화HPLC비교임신각개시기여비임신대서신장미혈관세포색소P450표체여활성.결과 여비임신대서상비,임신만기대서평균동맥압화신미혈관조력명현하강(P＜0.05),임신기CYP표체증가,산생EETs활성증가.결론 임신기신장혈류동역학변화가능여신장미혈관세포색소P450표체유관.
Objective To study the relation of renal microvessel cytochrome P450 expression and renal hemodynamics.Methods Compared the difference of renal hemodynamics between late-pregnant and virgin rats,and western blot and HPLC were used to compare the renal microvessel cytochrome P450 expression and activity.Results Comparing with virgin rats,both mean blood pressure and renal vessel resistance decreased in late-pregnant rata(P＜0.05),and the renal microvessel cytochrome P450 expression and activity increased.Conclusion These results demonstrated the change of renal hemodynamics in pregnancy might relate to the renal microvessel cytochrome P450 expression
