CAJ | 학술논문

目的探讨尼美舒利短期用于小儿退热治疗的疗效及安全性.方法通过与两种小儿常用退热药的对比治疗进行评价.将99例上呼吸道感染伴高热的患儿,随机分为Ⅰ、Ⅱ、Ⅲ三组,分别予口服尼美舒利、对乙酰氨基酚、布洛芬治疗,疗程≤3天.观察不良反应(ADRs)及首次用药后体温变化情况.结果尼美舒利组(Ⅰ组)在治疗后1h、4 h、6h的体温下降及退热持续总有效率与其他两组比较,P均＜0.01;不良反应发生率Ⅰ组与Ⅱ、Ⅲ组比较P均＜0.05,Ⅰ组大量出汗较突出,与其它两组比较P＜0.05.结论尼美舒利比其它两药退热起效快、持续时间较长、不良反应少,但大量出汗较明显.认为短期应用尚安全.
목적 탐토니미서리단기용우소인퇴열치료적료효급안전성.방법 통과여량충소인상용퇴열약적대비치료진행평개.장99례상호흡도감염반고열적환인,수궤분위Ⅰ、Ⅱ、Ⅲ삼조,분별여구복니미서리、대을선안기분、포락분치료,료정≤3천.관찰불량반응(ADRs)급수차용약후체온변화정황.결과 니미서리조(Ⅰ조)재치료후1h、4 h、6h적체온하강급퇴열지속총유효솔여기타량조비교,P균＜0.01;불량반응발생솔Ⅰ조여Ⅱ、Ⅲ조비교P균＜0.05,Ⅰ조대량출한교돌출,여기타량조비교P＜0.05.결론 니미서리비기타량약퇴열기효쾌、지속시간교장、불량반응소,단대량출한교명현.인위단기응용상안전.
Objective To investigate the safety and efficacy of short-term therapy with nimesulide for children with high fever. Methods The efficacy of two types of antifebrile drug was assessed. 99 children with upper respiratory tract infection were randomly assigned to receive oral nimesulide (group Ⅰ), acetami-nophen (group Ⅱ), or Ibuprofen (group Ⅲ) for 3 days or shorter. The adverse reactions and the changes in body temperature after the first treatment were observed. Results The total effective rates of body temperature decrease and defervesce time in group Ⅰ were compared with those in the other two groups (P<0.01). The incidence of adverse reactions was compared between group Ⅰ and groups Ⅱ and Ⅲ(P<0.05). More children has profuse sweating in group Ⅰ than in groups Ⅱ and Ⅲ(P<O.05). Conclusions Nimesulide has a quicker onset of antifebrile, longer lasting time, less adverse reactions but causes profuse sweating more obviously. The short-term therapy with nimesulide is safe.