中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
18期
16-18
,共3页
才海燕%高彩云%王敏%闫爱霞%王淑中%杨宇艳
纔海燕%高綵雲%王敏%閆愛霞%王淑中%楊宇豔
재해연%고채운%왕민%염애하%왕숙중%양우염
幼红细胞增多症,胎儿%血液凝固%血小板计数
幼紅細胞增多癥,胎兒%血液凝固%血小闆計數
유홍세포증다증,태인%혈액응고%혈소판계수
Erythroblastosis,fetal%Blood coagulation%Platelet count
目的 探讨新生儿溶血病凝血功能的变化及其临床意义.方法 以新生儿溶血病(溶血病组)、非溶血性高胆红素血症(非溶血病组)患儿各60例为研究对象,同期出生的60例正常足月儿为对照组.测定各组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数.结果 溶血病组PT、APTT明显高于非溶血病组[(28.79±4.21)s比(18.98±241)s和(58.52±313)s比(47.26±5.81)s],且两组明显高于对照组[(13.81±1.83)s和(38.10±3.00)s],差异有统计学意义(P<0.05),而血小板计数比较差异无统计学意义(P>0.05).结论 新生儿溶血病有出血倾向,与血小板计数无关,而与PT、APTT延长有关,溶血程度越重,PT、APTT升高越明显.PT、APTT可作为新生儿溶血病患儿凝血功能检测的指标和疗效评价指标.
目的 探討新生兒溶血病凝血功能的變化及其臨床意義.方法 以新生兒溶血病(溶血病組)、非溶血性高膽紅素血癥(非溶血病組)患兒各60例為研究對象,同期齣生的60例正常足月兒為對照組.測定各組凝血酶原時間(PT)、活化部分凝血活酶時間(APTT)、血小闆計數.結果 溶血病組PT、APTT明顯高于非溶血病組[(28.79±4.21)s比(18.98±241)s和(58.52±313)s比(47.26±5.81)s],且兩組明顯高于對照組[(13.81±1.83)s和(38.10±3.00)s],差異有統計學意義(P<0.05),而血小闆計數比較差異無統計學意義(P>0.05).結論 新生兒溶血病有齣血傾嚮,與血小闆計數無關,而與PT、APTT延長有關,溶血程度越重,PT、APTT升高越明顯.PT、APTT可作為新生兒溶血病患兒凝血功能檢測的指標和療效評價指標.
목적 탐토신생인용혈병응혈공능적변화급기림상의의.방법 이신생인용혈병(용혈병조)、비용혈성고담홍소혈증(비용혈병조)환인각60례위연구대상,동기출생적60례정상족월인위대조조.측정각조응혈매원시간(PT)、활화부분응혈활매시간(APTT)、혈소판계수.결과 용혈병조PT、APTT명현고우비용혈병조[(28.79±4.21)s비(18.98±241)s화(58.52±313)s비(47.26±5.81)s],차량조명현고우대조조[(13.81±1.83)s화(38.10±3.00)s],차이유통계학의의(P<0.05),이혈소판계수비교차이무통계학의의(P>0.05).결론 신생인용혈병유출혈경향,여혈소판계수무관,이여PT、APTT연장유관,용혈정도월중,PT、APTT승고월명현.PT、APTT가작위신생인용혈병환인응혈공능검측적지표화료효평개지표.
Objective To investigate the clinical significance and coagulation function changes in newborn hemolytic disease. Method The newborn hemolytic disease ( 60 cases, hemolytic disease group ), non-hemolytic hyperbilirubinemia (60 cases, non-hemolytic hyperbilirubinemia group) and normal newborn (60 cases,control group) were selected as the study subjects, the prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured, and the blood platelet count at the same time was detected. Results PT and APTT in hemolytic disease group were higher than those in non-hemolytic hyperbilirubinemia group[(28.79 ?.21) s vs. (18.98?.41) s and (58.52?.13) s vs. (47.26?.81) s], and they were apparently higher than those in control group [(13.81 ?1.83) s and (38.10 ?3.00) s], the difference had statistic significance (P<0.05). There was no statistic significance to detect the blood platelet count (P> 0.05). Conclusions The newborn hemolytic disease has the bleeding tendency, and the bleeding tendency has no relationship with the quantity of the blood platelet, but relates to the extension of PT and APTT. The more serious the case is, the more obvious the PT and APTT rise. PT and APTT can be as the detection index and evaluating effect of the newborn hemolytic disease coagulation function.
