肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
12期
806-809
,共4页
刘博雅%张志培%李小飞%邓迎春%高坤祥%徐鉷%王鹏%程庆书
劉博雅%張誌培%李小飛%鄧迎春%高坤祥%徐鉷%王鵬%程慶書
류박아%장지배%리소비%산영춘%고곤상%서홍%왕붕%정경서
癌%非小细胞肺%腺苷三磷酸酶类%ABCG2
癌%非小細胞肺%腺苷三燐痠酶類%ABCG2
암%비소세포폐%선감삼린산매류%ABCG2
Carcinoma%non-small-cell lung%Adenosine triphosphatases%ABCG2
目的 分析ABCG2和空泡型ATP酶(V-ATPase)在非小细胞肺癌(NSCIC)病理分类、TNM分期、病理分级中表达的差异性以及相关性.方法 对92例NSCLC组织样本采用免疫组织化学EnVision法检测ABCG2和V-ATPase的表达.结果 ABCG2、V-ATPase在腺癌和鳞癌中有表达,差异有统计学意义(P=0.003、P=0.000).ABCG2在腺癌TNM分期中的表达差异有统计学意义(P=0.004),在鳞癌TNM分期中差异无统计学意义;在腺癌和鳞癌病理分级的表达差异有统计学意义(P=0.028、P:0.000).V-ATPase在腺癌TNM分期、鳞癌病理分级间的表达差异有统计学意义(P=0.026、P=0.002),在鳞癌的TNM分期、腺癌病理分级组间的表达差异无统计学意义.在总体样本及腺癌、鳞癌中ABCG2和V-ATPase的表达有相关性.结论 V-ATPase可能与ABCG2共同参与NSCLC的多药耐药机制.
目的 分析ABCG2和空泡型ATP酶(V-ATPase)在非小細胞肺癌(NSCIC)病理分類、TNM分期、病理分級中錶達的差異性以及相關性.方法 對92例NSCLC組織樣本採用免疫組織化學EnVision法檢測ABCG2和V-ATPase的錶達.結果 ABCG2、V-ATPase在腺癌和鱗癌中有錶達,差異有統計學意義(P=0.003、P=0.000).ABCG2在腺癌TNM分期中的錶達差異有統計學意義(P=0.004),在鱗癌TNM分期中差異無統計學意義;在腺癌和鱗癌病理分級的錶達差異有統計學意義(P=0.028、P:0.000).V-ATPase在腺癌TNM分期、鱗癌病理分級間的錶達差異有統計學意義(P=0.026、P=0.002),在鱗癌的TNM分期、腺癌病理分級組間的錶達差異無統計學意義.在總體樣本及腺癌、鱗癌中ABCG2和V-ATPase的錶達有相關性.結論 V-ATPase可能與ABCG2共同參與NSCLC的多藥耐藥機製.
목적 분석ABCG2화공포형ATP매(V-ATPase)재비소세포폐암(NSCIC)병리분류、TNM분기、병리분급중표체적차이성이급상관성.방법 대92례NSCLC조직양본채용면역조직화학EnVision법검측ABCG2화V-ATPase적표체.결과 ABCG2、V-ATPase재선암화린암중유표체,차이유통계학의의(P=0.003、P=0.000).ABCG2재선암TNM분기중적표체차이유통계학의의(P=0.004),재린암TNM분기중차이무통계학의의;재선암화린암병리분급적표체차이유통계학의의(P=0.028、P:0.000).V-ATPase재선암TNM분기、린암병리분급간적표체차이유통계학의의(P=0.026、P=0.002),재린암적TNM분기、선암병리분급조간적표체차이무통계학의의.재총체양본급선암、린암중ABCG2화V-ATPase적표체유상관성.결론 V-ATPase가능여ABCG2공동삼여NSCLC적다약내약궤제.
Objective To investigate the expressions of ABCG2 and V-ATPase in NSCLC and their expression rates in pathological classification, TNM stages and pathological grades and the expression correlation between ABCG2 and V-ATPase. Methods Expressions of ABCG2 and V-ATPase were accessed with EnVinsion immunohistochemistry in tumor samples from 92 NSCLC patients. The corresponding data was analyzed statistically. Results Expressions of ABCG2 and V -ATPase were found both in the lung adenocarcinoma and lung squamous cell cancer, and the difference between these two kinds of tumors was significant (P =0.003,0.000). ABCG2 expression was significantly different among TNM stages of lung adenocarcinoma (P=0.004) as well as among pathological grades of lung adenocarcinoma (P =0.028) and squamous cell carcinoma (P =0.000), while no significant difference was found among TNM stages of squamous cell lung carcinoma. The level of V-ATPase expression was associated with TNM stages of lung adenocarcinoma (P =0.026) and pathological grades of lung squamous cell carcinoma (P =0.002), however, among TNM stages of lung squamous cell carcinoma and pathological grades of lung adenocarcinoma, the difference was not significant. Additionally, the significant correlation was found between expression of ABCG2 and V-ATPase in all samples, adenocarcinoma and squamous cell carcinoma (P<0.001). Conclusion The significant correlation is found between expression of ABCG2 and V-ATPase, which indicate that they may co-work to participate in the mechanism of anticancer drug resistance.
