CAJ | 학술논문

目的:研究糖尿病合并心血管疾病对心率变异性( heart rate variability, HRV)的影响,探讨预测性指标. 方法:对 44例合并高血压、冠心病及 48例单纯糖尿病患者进行 24 h HRV时域分析,并进一步发现其昼夜变化规律,同时与年龄、性别相当的 62例正常人 HRV资料比较. 结果:①糖尿病患者各项时域分析指标均较正常组降低 (P< 0.05).②与单纯糖尿病患者比较,有心血管合并症的糖尿病患者 HRV参数中正常 R-R间期的标准差( standard deviation of all normal to normal RR intervals,SDNN)、每 5 min正常 R-R间期平均值的标准差 (standard deviation of all mean 5 minute RR intervals, SDANN)、每 5 min正常 R-R间期标准差的平均值 (mean of the standard deviation of all NN inrervals for all 5 min segments,SDNN-index)、相邻正常 R-R间期差值的均方根值 (the root mean square successive differences,RMSSD)明显降低 (P< 0.05).③昼夜资料分析显示糖尿病患者白天和夜间 SDNN、 SDNN-index、 RMSSD、相邻正常 R-R间期差值 >50 ms 的计算占总 R-R间期数和百分比 (percent of the number of time that the difference between adjacent normal RR intervals is greater than 50 ms in the total number of NN intervals,PNN50)均较正常组明显降低 (P< 0.05);合并高血压、冠心病的糖尿病患者测值改变更加明显 (P< 0.05). 结论:糖尿病患者存在着 HRV异常,其异常的程度与病情轻重呈正比,有心血管合并症者昼夜节律异常更加显著.提示糖尿病患者的 HRV分析有助于预测恶性心血管事件的发生.
목적:연구당뇨병합병심혈관질병대심솔변이성( heart rate variability, HRV)적영향,탐토예측성지표. 방법:대 44례합병고혈압、관심병급 48례단순당뇨병환자진행 24 h HRV시역분석,병진일보발현기주야변화규률,동시여년령、성별상당적 62례정상인 HRV자료비교. 결과:①당뇨병환자각항시역분석지표균교정상조강저 (P< 0.05).②여단순당뇨병환자비교,유심혈관합병증적당뇨병환자 HRV삼수중정상 R-R간기적표준차( standard deviation of all normal to normal RR intervals,SDNN)、매 5 min정상 R-R간기평균치적표준차 (standard deviation of all mean 5 minute RR intervals, SDANN)、매 5 min정상 R-R간기표준차적평균치 (mean of the standard deviation of all NN inrervals for all 5 min segments,SDNN-index)、상린정상 R-R간기차치적균방근치 (the root mean square successive differences,RMSSD)명현강저 (P< 0.05).③주야자료분석현시당뇨병환자백천화야간 SDNN、 SDNN-index、 RMSSD、상린정상 R-R간기차치 >50 ms 적계산점총 R-R간기수화백분비 (percent of the number of time that the difference between adjacent normal RR intervals is greater than 50 ms in the total number of NN intervals,PNN50)균교정상조명현강저 (P< 0.05);합병고혈압、관심병적당뇨병환자측치개변경가명현 (P< 0.05). 결론:당뇨병환자존재착 HRV이상,기이상적정도여병정경중정정비,유심혈관합병증자주야절률이상경가현저.제시당뇨병환자적 HRV분석유조우예측악성심혈관사건적발생.