CAJ | 학술논문

背景:应用超声诊断胎儿中枢系统畸形已成为常用方法,但对胚胎发育过程中组织学特征与畸形相关性的细致研究尚不多.目的:探讨超声诊断胎儿中枢神经系统畸形的价值及畸形特征与诊断准确率的关系.设计:回顾性研究.地点、对象和方法:对美国加州一产前诊断中心5年中超声发现的148例中枢神经系统畸形的孕妇胎儿检查结果进行声像图特点分析.主要观察指标:148例中枢神经系统畸形的孕妇胎儿胎头双顶径、头围、侧脑室、延髓池、脑中线、颅骨光环、脊柱形态、羊水量超声检查结果.结果:148例中枢神经系统畸形胎儿中,无脑儿32例,脑积水3l例,积水性无脑4例,脑膜或脑脑膜膨出11例,脊柱裂脊膜膨出者25例,Dandy-Walker畸形12例,前脑无裂畸形11例,脉络丛囊22例,不同类型的中枢神经系统畸形有不同声像图表现,并与其胚胎发育过程异常相关.结论:高分辨率超声能准确地发现胎儿中枢神经系统各种畸形,在胎儿中枢神经系统畸形的诊断中有重要价值.
배경:응용초성진단태인중추계통기형이성위상용방법,단대배태발육과정중조직학특정여기형상관성적세치연구상불다.목적:탐토초성진단태인중추신경계통기형적개치급기형특정여진단준학솔적관계.설계:회고성연구.지점、대상화방법:대미국가주일산전진단중심5년중초성발현적148례중추신경계통기형적잉부태인검사결과진행성상도특점분석.주요관찰지표:148례중추신경계통기형적잉부태인태두쌍정경、두위、측뇌실、연수지、뇌중선、로골광배、척주형태、양수량초성검사결과.결과:148례중추신경계통기형태인중,무뇌인32례,뇌적수3l례,적수성무뇌4례,뇌막혹뇌뇌막팽출11례,척주렬척막팽출자25례,Dandy-Walker기형12례,전뇌무렬기형11례,맥락총낭22례,불동류형적중추신경계통기형유불동성상도표현,병여기배태발육과정이상상관.결론:고분변솔초성능준학지발현태인중추신경계통각충기형,재태인중추신경계통기형적진단중유중요개치.
BACKGROUND: Ultrasonic diagnosis has been a useful method in fetuses with central nervous system (CNS) deformities. But further study about the correlation between histological features and these deformities during the developmeut of embryo is rare.OBJECTIVE: To study the significance of ultrasonic diagnosis in fetuses with CNS deformities and the relationship between deformity features and the accuracy rate of diagnosis.DESIGN: A retrospective study.SETTING, PARTICIPANTS and INTERVENTIONS: Ultrasound images of 148 fetuses with CNS deformities were analyzed who were discovered through ultrasonic exanfination in a Prenatal Diagnostic Center in California of USA within 5 years.MAIN OUTCOME MEASURES: Biparietal diameter of fetal head, head circunfference, lateral ventricle, medullary cistern, brain median line, diaphragm of cranial bone, appearance of vertebral column and quantity of amniotic fluid were observed through ultrasonic examination.RESULTS: Thirty-two cases were anencephalia, 31 hydrocephalus, 4 hydroancncephalus, 11 neningocele or encephalomeningocele, 25 spinal meningocele with myeloschisis, 12 Dandy-Walker deformity, 11 schizencephaly of forebrain and 22 choroid plexus cyst among the 148 fetuses. There were different expressions in various CNS deformities, which were correlated with abnormal development of embryo.CONCLUSION: Ultrasound of high resolving power can accurately discover fetuses with different CNS deformities and which is of great significance in diagnosing these deformities.