国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2009年
6期
562-563
,共2页
肿瘤%免疫球蛋白轻链%散射测浊法和比浊法
腫瘤%免疫毬蛋白輕鏈%散射測濁法和比濁法
종류%면역구단백경련%산사측탁법화비탁법
Neoplasms%Immunoglobulin light chains%Nephelometry and turbidimetry
目的 探讨恶性肿瘤患者血清中Kappa和Lambda轻链的表达情况.方法 采用免疫散射比浊法对60例恶性肿瘤患者和15例健康体检者血清中Kappa和Lambda轻链进行榆测.结果 肝痛组患者血清中κ和λ值均显著高于健康对照组,且差异有统计学意义(P＜0.01);而κ/λ比值与健康对照组比较,差异尤统计学意义(P＞0.05).胃癌、肺癌、直肠/结肠癌、乳腺癌、食道癌组患者血清中κ、λ、κ/λ比值分别与健康对照组比较,差异无统计学意义(P＞0.05).结论 血清中Kappa和Lambda轻链检测,可作为原发性肝癌的试验诊断指标和对患者体液免疫功能的评价与监测.
目的 探討噁性腫瘤患者血清中Kappa和Lambda輕鏈的錶達情況.方法 採用免疫散射比濁法對60例噁性腫瘤患者和15例健康體檢者血清中Kappa和Lambda輕鏈進行榆測.結果 肝痛組患者血清中κ和λ值均顯著高于健康對照組,且差異有統計學意義(P＜0.01);而κ/λ比值與健康對照組比較,差異尤統計學意義(P＞0.05).胃癌、肺癌、直腸/結腸癌、乳腺癌、食道癌組患者血清中κ、λ、κ/λ比值分彆與健康對照組比較,差異無統計學意義(P＞0.05).結論 血清中Kappa和Lambda輕鏈檢測,可作為原髮性肝癌的試驗診斷指標和對患者體液免疫功能的評價與鑑測.
목적 탐토악성종류환자혈청중Kappa화Lambda경련적표체정황.방법 채용면역산사비탁법대60례악성종류환자화15례건강체검자혈청중Kappa화Lambda경련진행유측.결과 간통조환자혈청중κ화λ치균현저고우건강대조조,차차이유통계학의의(P＜0.01);이κ/λ비치여건강대조조비교,차이우통계학의의(P＞0.05).위암、폐암、직장/결장암、유선암、식도암조환자혈청중κ、λ、κ/λ비치분별여건강대조조비교,차이무통계학의의(P＞0.05).결론 혈청중Kappa화Lambda경련검측,가작위원발성간암적시험진단지표화대환자체액면역공능적평개여감측.
Objective To investigate the abnormal expressions of immunoglobulin light chains kappa(Igκ)and Lambda(Igλ)in malignant tumors.Methods The concentrations of the Igκ and Igλ in serum were measured by rat nephelometry in 60 cases of malignant tumors and 15 cases of healthy people.Results The liver tumor patients had a higher concentration of Igκ and Igλ in serum than normal people(P＜0.01).There wre not significant differences between the levels of Igκ,Igλ and κ/λ ratio in the stomach tumor,lung tumor,proctologic/colonic tumor,mammary tumor,oesophagus tumor and normal peoples(P＞0.05).Conclusion The measurment of Igκ,Igλ and κ/λ ratio in serum would be helpful for the diagnosis of the liver tumor.By continous observation with Igκ,Igλ and κ/λratio in serum could predict the development of disease.
