CAJ | 학술논문

目的探讨脑淀粉瘤的临床病理特征、免疫表型及其鉴别诊断.方法应用常规病理及免疫组化和组织化学观察1例脑淀粉瘤,并复习相关文献.结果组织学上,肿瘤主要由粉红色无结构如带壳栗子状的沉着组成,病灶周围有淋巴细胞浸润,未见胶质成分;边缘神经细胞排列松散,有粉红的无结构沉着物质,毛细血管增生不明显,血管壁未见淀粉样改变,脑水肿不明显.免疫组化示肿瘤细胞嗜刚果红染色.病灶周围T淋巴细胞CD3和GFAP(+).结论脑淀粉瘤是一种少见的特殊类型脑内良性肿瘤,肿瘤发生原因复杂,嗜刚果红染色是有效的诊断方法.
목적 탐토뇌정분류적림상병리특정、면역표형급기감별진단.방법 응용상규병리급면역조화화조직화학관찰1례뇌정분류,병복습상관문헌.결과 조직학상,종류주요유분홍색무결구여대각률자상적침착조성,병조주위유림파세포침윤,미견효질성분;변연신경세포배렬송산,유분홍적무결구침착물질,모세혈관증생불명현,혈관벽미견정분양개변,뇌수종불명현.면역조화시종류세포기강과홍염색.병조주위T림파세포CD3화GFAP(+).결론 뇌정분류시일충소견적특수류형뇌내량성종류,종류발생원인복잡,기강과홍염색시유효적진단방법.
Objective To explore the clinical pathologic features, immunophenotype and differentiatial diagnosis of primary intracerebral amyloidoma. Methods Application of conventional pathological and immunohistochemical and histochemical techniques were used in one cases of brain tumor with review of the literatures. Results Histologically,the tumor was composed of pink shell structures such as the chestnut-like calm. The lesion was surrounded by infiltrating lymphocytes,and there was no microglia element with the edge of nerve cells arranged in a loose, pink-non- structure material components. Capillary proliferation was not obvious, and no amyloid changes were found in vescular wall. Brain edema was not obvious. Histochemistry showed the tumor cells were positive to Congo red staining. T-infiltrating lymphocytes around the lesion were CD3(+) and GFAP(+). Conclusion Primary intracerebral amyloidoma is a rare, and benign intracerebral lesion with complex etiology. Congo red stain is an effective method for diagnosis of intracerebral amyloidoma.