CAJ | 학술논문

MicroRNA(miRNA)是一类由多细胞真核生物编码的长度约为22个核苷酸的调控RNA分子,它们在许多重要细胞过程中参与转录后基因表达调控.某些病毒也能编码miRNA.目前发现的病毒miRNA已经超过200种,病毒利用这些miRNA可以调节细胞及其自身的基因表达.此文就编码miRNA的病毒,病毒miRNA的作用机制、生物学功能、保守性及其与疾病治疗的关系等内容进行综述.
MicroRNA(miRNA)시일류유다세포진핵생물편마적장도약위22개핵감산적조공RNA분자,타문재허다중요세포과정중삼여전록후기인표체조공.모사병독야능편마miRNA.목전발현적병독miRNA이경초과200충,병독이용저사miRNA가이조절세포급기자신적기인표체.차문취편마miRNA적병독,병독miRNA적작용궤제、생물학공능、보수성급기여질병치료적관계등내용진행종술.
MicroRNAs(miRNAs) are 22-nt regulatory RNAs expressed by all muhicellular eukaryotes.These regulatory RNAs provide a unique level of posttranscriptional gene regulation that modulates a range of fundamental cellular processes.Several viruses also encode miRNAs,and over 200 viral miRNAs have now been identified.Current evidence indicates that viruses use these miRNAs to manipulate both cellular and viral gene expression.The current knowledge of the viruses that encode miRNAs,mechanisms of action and biological function of virally-encoded miRNAs,conservation and theraputic development of vral miRNAs are reviewed in this paper.