CAJ | 학술논문

目的评价国产厄贝沙坦对老年原发性高血压的疗效及对肾功能的保护作用.方法 42例确诊为原发性高血压的老年患者,服用国产厄贝沙坦150mg,每日1次,每1～2周随访1次,若服药后降压效果不理想,可加大至300 mg/d,治疗8周,监测治疗前后24 h动态血压水平及肾功能指标.结果国产厄贝沙坦治疗后,患者24 h平均收缩压和舒张压、日间及夜间收缩压和舒张压均有明显下降(P＜0.05或＜0.01);血及尿B2-微球蛋白明显减少[(5.9±3.3)μg/L比(2.6±2.6)μg/L,(811.2±97.2)mmol/L比(457.6±69.8)emmol/L].结论国产厄贝沙坦不仅对老年原发性高血压患者有良好的平稳降压效果,而且对其肾功能亦有良好的保护作用.
목적 평개국산액패사탄대노년원발성고혈압적료효급대신공능적보호작용.방법 42례학진위원발성고혈압적노년환자,복용국산액패사탄150mg,매일1차,매1～2주수방1차,약복약후강압효과불이상,가가대지300 mg/d,치료8주,감측치료전후24 h동태혈압수평급신공능지표.결과 국산액패사탄치료후,환자24 h평균수축압화서장압、일간급야간수축압화서장압균유명현하강(P＜0.05혹＜0.01);혈급뇨B2-미구단백명현감소[(5.9±3.3)μg/L비(2.6±2.6)μg/L,(811.2±97.2)mmol/L비(457.6±69.8)emmol/L].결론 국산액패사탄불부대노년원발성고혈압환자유량호적평은강압효과,이차대기신공능역유량호적보호작용.
Objective To evaluate the effects of domestic irbesartan on blood pressure and renal function in the aged with primary hypertension.Methods Renal function,plasma and urine β2 microglob ulin WBS measured and blood pressure was investigated by 24-hour ambulatory blood monitoring in 42 aged with primary hypertension who received domestic irbesartan(1 50 mg/d,followed up every 1-2 weeks.If the effect was not ideal,the dose could be added to 300 mg/d)in 8-week's treatment.Results After the treatment.24 hours recall systolic blood pressure,24-hour mean diastolic blood pressure,mean day systolic blood pressure,mean day diastolic blood pressure,mean night systolic blood pressure,mean night diastolic blood pressure were significantly reduced.At the same time,domestic irbesartan induced a remarkable reduction of plasma and urine β2 microglobulin [(5.9±3.3)μg/L vs(2.6±2.6)μg/L, (811.2±97.2) mmol/L vs(457.6±69.8)mmol/L,respectively].Conclusion The antihypertensive effects of domestic irbesartan can persist for 24-hour and Can reduce urinary protein.