中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2009年
6期
365-369
,共5页
乳腺癌%癌胚抗原%糖类抗原153%糖类抗原125
乳腺癌%癌胚抗原%糖類抗原153%糖類抗原125
유선암%암배항원%당류항원153%당류항원125
Breast cancer%CEA%CA-125%CA15-3
目的 研究乳腺癌患者术后血清CA15-3、CEA和CA-125水平与乳腺癌各种临床资料以及病情转归的关系.方法 收集我院收治的临床信息完整的219例乳腺癌术后病例.应用化学发光免疫法检测血清CA15-3、CEA和CA-125浓度,统计分析其与各临床参数以及病情转归的关系.结果 乳腺癌转移时,血清CA15-3、CEA和CA-125水平均明显高于未转移组(P=0.000),且三项指标联合检测敏感性达64.1%.转移时血清CA-125和CA15-3水平与ER呈正相关(PCA-125=0.049,PCA15-3=0.039).多脏器转移者血清CA15-3、CEA和CA-125浓度明显高于单脏器转移者(P=0.000).远处转移病例CA15-3和CEA水平与局部复发病例存在统计学差异(PCA15-3=0.001,PCEA=0.022).结论 血清CA15-3、CEA和CA-125浓度升高与否是监测乳腺癌转移的有效指标.乳腺癌转移时血清CA15-3和(或)CA-125浓度升高可提示患者对内分泌治疗更敏感.
目的 研究乳腺癌患者術後血清CA15-3、CEA和CA-125水平與乳腺癌各種臨床資料以及病情轉歸的關繫.方法 收集我院收治的臨床信息完整的219例乳腺癌術後病例.應用化學髮光免疫法檢測血清CA15-3、CEA和CA-125濃度,統計分析其與各臨床參數以及病情轉歸的關繫.結果 乳腺癌轉移時,血清CA15-3、CEA和CA-125水平均明顯高于未轉移組(P=0.000),且三項指標聯閤檢測敏感性達64.1%.轉移時血清CA-125和CA15-3水平與ER呈正相關(PCA-125=0.049,PCA15-3=0.039).多髒器轉移者血清CA15-3、CEA和CA-125濃度明顯高于單髒器轉移者(P=0.000).遠處轉移病例CA15-3和CEA水平與跼部複髮病例存在統計學差異(PCA15-3=0.001,PCEA=0.022).結論 血清CA15-3、CEA和CA-125濃度升高與否是鑑測乳腺癌轉移的有效指標.乳腺癌轉移時血清CA15-3和(或)CA-125濃度升高可提示患者對內分泌治療更敏感.
목적 연구유선암환자술후혈청CA15-3、CEA화CA-125수평여유선암각충림상자료이급병정전귀적관계.방법 수집아원수치적림상신식완정적219례유선암술후병례.응용화학발광면역법검측혈청CA15-3、CEA화CA-125농도,통계분석기여각림상삼수이급병정전귀적관계.결과 유선암전이시,혈청CA15-3、CEA화CA-125수평균명현고우미전이조(P=0.000),차삼항지표연합검측민감성체64.1%.전이시혈청CA-125화CA15-3수평여ER정정상관(PCA-125=0.049,PCA15-3=0.039).다장기전이자혈청CA15-3、CEA화CA-125농도명현고우단장기전이자(P=0.000).원처전이병례CA15-3화CEA수평여국부복발병례존재통계학차이(PCA15-3=0.001,PCEA=0.022).결론 혈청CA15-3、CEA화CA-125농도승고여부시감측유선암전이적유효지표.유선암전이시혈청CA15-3화(혹)CA-125농도승고가제시환자대내분비치료경민감.
Objective To investigate the relationship between serum levels of CA15-3, CA-125 and CEA in postoperative breast cancer patients and clinicopathological parameters and pathogenetic condition turnover. Methods From January 2004 to December 2007, 219 breast disease cases with integrity clinical information, admitted to general surgery and oncology department of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, were collected. The serum concentrations of CA15-3, CA-125 and CEA were determined by chemiluminescent immunoassay(CLIA). Wilcoxon Kruskal Wallis analysis, crosstable analysis and spearman correlation analysis were used to investigate the association between the serum concentration and clinical parameters and pathogenetic condition turnover. Results The serum concentrations of CA15-3,CA-125 and CEA in metastatic breast cancer group were significantly higher than those in nonmetastatic group(P=0.000). The sensitivity of the 3 tumor markers in combination was 64.1% in metastatic breast cancer diagnosis. CA15-3 and CA-125 at the time of initial metastasis were correlated with estrogen receptor state(PCA15-3=0.039, PCA-125=0.049). The level of 3 tumor markers in multiorgan metastatic group were significantly higher than those in single organ metastastic patients(P=0.000). There were significant differences between the levels of CA15-3 and CEA in distant metastatic group and those in local metastatic group (PCA15-3=0.001,PCEA=0.022). Conclusion The high serum concentrations of CA15-3,CEA and CA-125 were useful in monitoring the metastasis. The high serum levels of CA15-3 and/or CA-125 may indicate that the patients will be more sensitive to endocrine therapy.