CAJ | 학술논문

目的总结累及眶内肿瘤的伽玛刀治疗效果.方法共治疗累及眶内的肿瘤患者35例,随访25例(脑膜瘤16例,脑膜血管外皮细胞瘤3例,神经鞘瘤2例,腺样囊性癌2例,转移癌1例,血管纤维瘤1例),采取1.5T PHILIPS或3.0T GE磁共振2 mm薄层扫描定位,Kula或GammaPlan剂量计划系统.肿瘤平均体积2.91 cm3(0.17～19.50 cm3),平均周边剂量12.4 Gy(8～15 Gy),中心剂量26.7 Gy(16～32 Gy).结果本组随访期为1-62个月,平均30.4个月,23例控制满意,总体控制率为92%;6例(24%)症状减轻,13例(52%)症状无改变,5例(20%)出现了一过性的新发或原有症状加重;2例肿瘤增大,其中1例因突眼加重而行手术治疗.结论对于累及眶内的较小病变、或经手术治疗后残留、复发等不宜手术治疗的病例,伽玛刀治疗可作为综合治疗的重要手段.
목적 총결루급광내종류적가마도치료효과.방법 공치료루급광내적종류환자35례,수방25례(뇌막류16례,뇌막혈관외피세포류3례,신경초류2례,선양낭성암2례,전이암1례,혈관섬유류1례),채취1.5T PHILIPS혹3.0T GE자공진2 mm박층소묘정위,Kula혹GammaPlan제량계화계통.종류평균체적2.91 cm3(0.17～19.50 cm3),평균주변제량12.4 Gy(8～15 Gy),중심제량26.7 Gy(16～32 Gy).결과 본조수방기위1-62개월,평균30.4개월,23례공제만의,총체공제솔위92%;6례(24%)증상감경,13례(52%)증상무개변,5례(20%)출현료일과성적신발혹원유증상가중;2례종류증대,기중1례인돌안가중이행수술치료.결론 대우루급광내적교소병변、혹경수술치료후잔류、복발등불의수술치료적병례,가마도치료가작위종합치료적중요수단.
Objective To investigate the outcomes of gamma knife treatment of patients with tumors involving orbit. Methods From 1995 to 2008, 35 patients with tumors involving orbit were treated by Leksell Gamma Knife in our center. 25 patients ( 16 meningiomas, 3 meningeal hemangiopericytomas, 2 schwannomas, 2 adenoid cystic carcinomas of the lacrimal gland, 1 metastatic tumor and 1 angiofibroma)were followed - up. MRI ( 1.5T PHILIPS or 3. 0T GE ) with 2 - mm thick slice was performed to acquire images for targeting tumors and Kula or GammaPlan was used. The mean tumor volume was 2.91 cm3 (0.17～ 19.50 cm3 ). The median marginal dose was 12. 4 Gy (8 ～ 15 Gy) and the median center dose was 26. 7 Gy ( 16 ～ 32 Gy) . Result After a mean follow - up of 30. 4 months ( 1 - 62 months) for 25 patients,tumor control was confirmed in 23(92％ ) patients. 6(24％ ) patients got symptoms relieved and 13(52％)stable. Transient symptoms development was observed in 5 ( 20％ ) patients. Of the 2 patients with tumor progression, 1 patient had to undergo another operation due to developed exophthalmos. Conclusions Gamma knife may be an effective treatment option for small or residual tumors involving orbit.