CAJ | 학술논문

目的探讨苦参素联合甘草酸二铵对慢性乙型肝炎(CHB)患者特异性细胞免疫的影响.方法 63例CHB患者随机分为2组,苦参素联合甘草酸二铵组(联合组)32例,用苦参素葡萄糖注射液600 mg,静脉滴注,每日1次,1个月后改为苦参素胶囊200 mg口服,每日3次,2个月.甘草酸二铵注射液150 mg加入10％葡萄糖注射液250 ml中静脉滴注,每日1次,1个月后改为甘草酸二铵胶囊150 mg口服,每日3次,2个月；苦参素组(单用组)31例,只用苦参素,用法用量同治疗组.比较两组患者的HBV特异性细胞毒T细胞(CTL)、T细胞亚群、Th1、Th2水平的变化和HBV-DNA、HBeAg阴转率.结果联合组治疗3个月后,HBV特异性CTL、CD4+、Th1高于治疗前,也高于单用组治疗后(P＜0.01).HBV-DNA和HBeAg阴转率两组比较差异无统计学意义(P＞0.05).结论苦参素联合甘草酸二铵能进一步提高CHB患者的HBV特异性CTL、CD4+和Th1水平.
목적 탐토고삼소연합감초산이안대만성을형간염(CHB)환자특이성세포면역적영향.방법 63례CHB환자수궤분위2조,고삼소연합감초산이안조(연합조)32례,용고삼소포도당주사액600 mg,정맥적주,매일1차,1개월후개위고삼소효낭200 mg구복,매일3차,2개월.감초산이안주사액150 mg가입10％포도당주사액250 ml중정맥적주,매일1차,1개월후개위감초산이안효낭150 mg구복,매일3차,2개월；고삼소조(단용조)31례,지용고삼소,용법용량동치료조.비교량조환자적HBV특이성세포독T세포(CTL)、T세포아군、Th1、Th2수평적변화화HBV-DNA、HBeAg음전솔.결과 연합조치료3개월후,HBV특이성CTL、CD4+、Th1고우치료전,야고우단용조치료후(P＜0.01).HBV-DNA화HBeAg음전솔량조비교차이무통계학의의(P＞0.05).결론 고삼소연합감초산이안능진일보제고CHB환자적HBV특이성CTL、CD4+화Th1수평.
Objective To explore effects of kurarinol combined with Diammonium Glycyrrhizinate on specific cellular immunity of patients with chronic hepatitis B ( CHB ).Methods Sixty-three CHB patients were randomly divided into two groups,32 cases in group of kurarinol combined with Diammonium Glycyrrhizinate group (combined therapy group )were treated with 600 mg kurarinol glucose injection intravenously,once a day for one month,then 200 mg kurarinol capsule was used orally,three times a day for two months.150 mg Diammonium Glycyrrhizinate for Injection was added to 250 ml 10％ glucose injection for intravenous drip,once a day for one month,then 150 mg Diammonium Glycyrrhizinate capsule was used orally,three times a day for two months;31 case in kurarinol group( single drug group)only used kurarinol,methods and dosage were the same as those of treatment group.HBV specific CTL,T cell subgroups,change of Th1 and Th2 leveI,HBV-DNA and HBeAg negative rate of the two groups were compared.Results Three months after treatment,HBV specific CTL,CD4 + and Th1 of combined therapy group were higher than those before treatment,and higher than those of single drug group after treatment ( P ＜ 0.01 ).Conclusion HBV-DNA and HBeAg negative rate between the two groups had no statistic significance ( P ＞ 0.05 ).Conclusion Kurarinol combined with Diammonium Glycyrrhizinate can further increase HBV specific CTL,CD4 + and Th1 level of CHB patients.