中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2011年
3期
244-248
,共5页
陈万青%贺宇彤%孙喜斌%温登瑰%陈志峰%赵德利
陳萬青%賀宇彤%孫喜斌%溫登瑰%陳誌峰%趙德利
진만청%하우동%손희빈%온등괴%진지봉%조덕리
消化系统肿瘤%食管%胃%病例对照研究%危险因素
消化繫統腫瘤%食管%胃%病例對照研究%危險因素
소화계통종류%식관%위%병례대조연구%위험인소
Digestive system neoplasms%Esophagus%Stomach%Case-control studies%Risk factors
目的 探讨我国食管癌、胃癌高发区目前上消化道3种恶性肿瘤发病的危险因素.方法 选择食管癌高发区河北省磁县、涉县,河南省林县和山东省肥城,胃癌高发区辽宁省庄河,每个地区分别从肿瘤登记数据库中选择发病日期为2009年1月1日以后的新诊断病例,利用随机数字表法选取食管下段癌、贲门癌、其他部位胃癌病例,共收集751例;按照病例与对照1∶3配对选取对照人群2253名.采用课题设计的调查表收集研究对象相关资料,并对相关变量进行单因素及多因素logistic回归分析,估计各危险因素的OR值(95%CI).结果 饮食不规律、经常食用油炸食品、有消化道病史及胃食管反流性疾病史者病例组分别有66、83、369、282例,而对照组分别为90、214、119、432名.单因素分析显示,以上因素可增加上消化道肿瘤发病风险[OR值(95%CI)分别为3.177(2.127～4.745)、3.190(2.061～4.927)、14.660(11.342～18.948)、3.137(2.546～3.864)];而常吃新鲜蔬菜者病例组中有387例,对照组有1278名,此因素可降低上消化道肿瘤发病风险(OR=0.609;95%CI:0.473～0.785).多因素分析显示,消化道病史(OR=21.420;95%CI:15.484～29.632)、饮食不规律(OR=3.097;95%CI:1.740～5.514)、经常食用腌晒食品(OR=3.005;95%CI:1.873～4.819)、胃食管反流性疾病史(OR=2.261;95%CI:1.673～3.057)等是上消化道肿瘤的危险因素;每天食用新鲜蔬菜(OR=0.562;95%CI:0.396～0.800)是上消化道肿瘤的保护因素.结论 不良生活方式和不健康饮食习惯是我国食管癌、胃癌高发区居民上消化道恶性肿瘤的危险因素.
目的 探討我國食管癌、胃癌高髮區目前上消化道3種噁性腫瘤髮病的危險因素.方法 選擇食管癌高髮區河北省磁縣、涉縣,河南省林縣和山東省肥城,胃癌高髮區遼寧省莊河,每箇地區分彆從腫瘤登記數據庫中選擇髮病日期為2009年1月1日以後的新診斷病例,利用隨機數字錶法選取食管下段癌、賁門癌、其他部位胃癌病例,共收集751例;按照病例與對照1∶3配對選取對照人群2253名.採用課題設計的調查錶收集研究對象相關資料,併對相關變量進行單因素及多因素logistic迴歸分析,估計各危險因素的OR值(95%CI).結果 飲食不規律、經常食用油炸食品、有消化道病史及胃食管反流性疾病史者病例組分彆有66、83、369、282例,而對照組分彆為90、214、119、432名.單因素分析顯示,以上因素可增加上消化道腫瘤髮病風險[OR值(95%CI)分彆為3.177(2.127～4.745)、3.190(2.061～4.927)、14.660(11.342～18.948)、3.137(2.546～3.864)];而常喫新鮮蔬菜者病例組中有387例,對照組有1278名,此因素可降低上消化道腫瘤髮病風險(OR=0.609;95%CI:0.473～0.785).多因素分析顯示,消化道病史(OR=21.420;95%CI:15.484～29.632)、飲食不規律(OR=3.097;95%CI:1.740～5.514)、經常食用醃曬食品(OR=3.005;95%CI:1.873～4.819)、胃食管反流性疾病史(OR=2.261;95%CI:1.673～3.057)等是上消化道腫瘤的危險因素;每天食用新鮮蔬菜(OR=0.562;95%CI:0.396～0.800)是上消化道腫瘤的保護因素.結論 不良生活方式和不健康飲食習慣是我國食管癌、胃癌高髮區居民上消化道噁性腫瘤的危險因素.
목적 탐토아국식관암、위암고발구목전상소화도3충악성종류발병적위험인소.방법 선택식관암고발구하북성자현、섭현,하남성림현화산동성비성,위암고발구요녕성장하,매개지구분별종종류등기수거고중선택발병일기위2009년1월1일이후적신진단병례,이용수궤수자표법선취식관하단암、분문암、기타부위위암병례,공수집751례;안조병례여대조1∶3배대선취대조인군2253명.채용과제설계적조사표수집연구대상상관자료,병대상관변량진행단인소급다인소logistic회귀분석,고계각위험인소적OR치(95%CI).결과 음식불규률、경상식용유작식품、유소화도병사급위식관반류성질병사자병례조분별유66、83、369、282례,이대조조분별위90、214、119、432명.단인소분석현시,이상인소가증가상소화도종류발병풍험[OR치(95%CI)분별위3.177(2.127～4.745)、3.190(2.061～4.927)、14.660(11.342～18.948)、3.137(2.546～3.864)];이상흘신선소채자병례조중유387례,대조조유1278명,차인소가강저상소화도종류발병풍험(OR=0.609;95%CI:0.473～0.785).다인소분석현시,소화도병사(OR=21.420;95%CI:15.484～29.632)、음식불규률(OR=3.097;95%CI:1.740～5.514)、경상식용업쇄식품(OR=3.005;95%CI:1.873～4.819)、위식관반류성질병사(OR=2.261;95%CI:1.673～3.057)등시상소화도종류적위험인소;매천식용신선소채(OR=0.562;95%CI:0.396～0.800)시상소화도종류적보호인소.결론 불량생활방식화불건강음식습관시아국식관암、위암고발구거민상소화도악성종류적위험인소.
Objective To explore the major risk factors for upper gastrointestinal cancer in high occurrence areas of esophageal and gastric cancer in China. Methods Four high occurrence areas of esophageal cancer, namely Cixian and Shexian from Hebei province, Linxian from Henan province, Feicheng from Shandong province, and Zhuanghe from Liaoning province, which is a high occurrence area of gastric cancer,were selected for the study. The newly-diagnosed cases whose date of onset were after January 1st,2009 were selected from the Cancer Registration Database in each district, and 751 cases diagnosed as cancers in lower segment of esophagus, cardiac and other subsite of stomach were randomly recruited. 2253 matched controls were selected to pair the cases at the ratio of 3: 1. The relative information of the study objects were collected from the face-to-face interviews with trained staff by designed questionnaires, and the data was input by EpiData software. Statistic software SPSS 13.0 was applied to conduct both univariate and multivariate logistic regression analysis to evaluate odd ratios (OR) and 95% confident interval (CI).Results As univariate analysis shown,66 objects in case group had irregular diet habit; while 90 in control group had ( OR= 3. 177;95% CI: 2. 127 - 4.745). A higher percentage in case group (83 objects)preferred fried food in comparison with only 214 in control group did (OR= 3. 190; 95% CI: 2.061 -4. 927). 369 objects in case group, but only 119 in control group had history of gastrointestinal diseases ( OR = 14. 660; 95% CI: 11. 342 - 18. 948 ). 282 objects in case group had history of gastroesophageal reflux disease (GERD) ,which was much higher than the percentage in control group (432 objects),with OR =3. 137 (95% CI: 2. 546 -3. 864). All the above factors could increase the risk for upper gastrointestinal cancer. 387 objects in case group and 1278 in control group reported they preferred fresh vegetables in daily diet,which was found to be a protective factor ( OR = 0. 609; 95% CI: 0. 473 - 0. 785 ). As multivariate analysis shown, history of gastrointestinal tract diseases ( OR = 21. 420; 95% CI: 15.484 - 29. 632 ),irregular food diet (OR=3.097; 95%CI: 1.740-5.514),pickled food (OR=3.005; 95%CI: 1.873 -4. 819) ,and GERD ( OR = 2. 261; 95% CI: 1. 673 - 3.057 ) were found to be risk factors for upper gastrointestinal cancer; while frequent fresh-vegetable diet was a protective factor (OR = 0. 562; 95% CI:0. 396 -0. 800). Conclusion Irregular lifestyle and unhealthy diet habit could be the major risk factors for upper gastrointestinal cancers among the residents from high occurrence areas of esophageal cancer and gastric cancer in China.
