CAJ | 학술논문

背景:低强度氦氖激光血管内照射疗法可以有效抑制戒断症状的发生,验证疗效假说需有定量化的标准评估.目的:自拟海洛因戒断症状标准评分,观察低强度氦氖激光血管内照射对戒断症状的抑制作用.设计:以海洛因吸毒患者为观察对象,随机对照试验.单位:新乡医学院分析测试实验室;郑州大学医学院激光医学研究中心.对象:实验于2003-01在郑州大学医学院激光医学研究中心完成.选择郑州戒毒所30名海洛因吸毒患者,其中男25例,女5例,年龄19～45岁,吸毒时间0.5～5.0年,吸毒量1.0～4.0 g/d,随机分为实验组15例和对照组15例.干预:实验组于人院次日采用低强度氦氖激光血管内照射疗法治疗,照射功率2.0～3.0mW,功率密度7.07～10.6mW/mm2,1次/d,60min/d,10 d为1个疗程,对照组采用美沙酮加盐酸丁丙诺啡(Me-Bup)常规戒毒疗法.观察毒瘾戒断者的12项突出症状,即呕吐、鸡皮疙瘩、出汗、烦躁不安、震颤、流泪、鼻充血、失眠、腹部变化、体温变化、肌肉痛、心率.每项症状按无、轻、中、重4级评分,分别记作0,1,2,3分,单项3分,总分36分.主要观察指标:两组患者治疗后戒断症状量化评分比较.结果:30例患者全部进入结果分析.实验组呕吐,失眠,烦躁,震颤,鸡皮疙瘩,腹痛的戒断症状评分[(2.0±0.5)分,(2.5±0.4)分,(4.6±0.3)分,(3.6±0.7)分,(3.1±0.3)分,(4.2±0.5)分]明显低于对照组[(5.1±0.7)分,(6.0±0.7)分,(7.4±0.6)分,(7.1±0.6)分,(5.7±0.6)分,(6.4±0.7)分,t=9.90～16.81,P＜0.01].结论:应用症状量化法评估,低强度氦氖激光血管内照射疗法可有效减轻海洛因戒断症状.
배경:저강도양내격광혈관내조사요법가이유효억제계단증상적발생,험증료효가설수유정양화적표준평고.목적:자의해락인계단증상표준평분,관찰저강도양내격광혈관내조사대계단증상적억제작용.설계:이해락인흡독환자위관찰대상,수궤대조시험.단위:신향의학원분석측시실험실;정주대학의학원격광의학연구중심.대상:실험우2003-01재정주대학의학원격광의학연구중심완성.선택정주계독소30명해락인흡독환자,기중남25례,녀5례,년령19～45세,흡독시간0.5～5.0년,흡독량1.0～4.0 g/d,수궤분위실험조15례화대조조15례.간예:실험조우인원차일채용저강도양내격광혈관내조사요법치료,조사공솔2.0～3.0mW,공솔밀도7.07～10.6mW/mm2,1차/d,60min/d,10 d위1개료정,대조조채용미사동가염산정병낙배(Me-Bup)상규계독요법.관찰독은계단자적12항돌출증상,즉구토、계피흘탑、출한、번조불안、진전、류루、비충혈、실면、복부변화、체온변화、기육통、심솔.매항증상안무、경、중、중4급평분,분별기작0,1,2,3분,단항3분,총분36분.주요관찰지표:량조환자치료후계단증상양화평분비교.결과:30례환자전부진입결과분석.실험조구토,실면,번조,진전,계피흘탑,복통적계단증상평분[(2.0±0.5)분,(2.5±0.4)분,(4.6±0.3)분,(3.6±0.7)분,(3.1±0.3)분,(4.2±0.5)분]명현저우대조조[(5.1±0.7)분,(6.0±0.7)분,(7.4±0.6)분,(7.1±0.6)분,(5.7±0.6)분,(6.4±0.7)분,t=9.90～16.81,P＜0.01].결론:응용증상양화법평고,저강도양내격광혈관내조사요법가유효감경해락인계단증상.
BACKGROUND: Intravascular low-level laser irradiation (ILLLI) therapy with He-Ne laser can effectively inhibit the occurrence of heroin withdrawal syndrome, but the therapeutic effect should be evaluated by quantitative standards.OBJECTIVE: To evaluate the effect of intravascular low-level He-Ne laser irradiation against withdrawal syndrome with intravenous according to the criteria proposed by the authors.DESIGN: Randomized controlled trial in heroin-addicted patients.SETTING: Analysis and Testing Laboratory of Xinxiang Medical College and Center of Laser Medical Research of Zhenzhou University Medical CollegePARTICIPANTS: The study was completed in Center of Laser Medical Research in Zhengzhou University in January 2003. Thirty heroin addicts from the Detoxification Center of Zhengzhou including 25 male and 5 female patients aged 19- 45 years were divided randomly into experimental group and control group with 15 cases in each. The patients' history of drug abuse ranged from 0. 5 to 5 years and the daily doses they took was 1.0-4.0 g.INTERVENTIONS: Patients in the experimental group were treated by ILLLI therapy after hospitalization. The therapy was administered once daily for 60 minutes in each session, for a total of 10 days for a treatment course. The irradiating power of the laser was 2.0-3.0 mW with a power density of 7.07-10.6 mW/mm2. Patients in the control group were treated with conventional therapy with algidon combined with buprenorphine hydrochloride. The 12 main symptoms(vomiting, goose pimples, sweating, agitation, shaking, lacrimation, nasal congestion, insomnia, abdominal pain,body temperature changes, muscular pain, and heart rate changes) were scored for 0, 1, 2, and 3 corresponding to absent, mild, moderate, and severe symptoms, with the total score of 36.MAIN OUTCOME MEASURES: Comparison of the scores for the withdrawal symptoms between the two groups.RESULTS: The 30 cases were all available for result analysis. The scores of vomiting, insomnia, agitation, shaking, goose pimples and abdominal pain in the experimental group were 2.0±0.5, 2.5±0.4,4.6±0.3,3.6±0.7,3.1±0.3 and 5.7±0.6 respectively, which were obviously lower than those in control group(5.1±0.7,6.0±0.7,7.4±0.6, 7.1±0.6,5.7±0.6 and 6.4 ±0.7 respectively, t =9.90-16. 81, P＜0.01).CONCLUSION: Intravascular low-level He-Ne laser irradiation can effectively relieve heroin withdrawal syndrome.