临床麻醉学杂志
臨床痳醉學雜誌
림상마취학잡지
THE JOURNAL OF CLINICAL ANESTHESIOLOGY
2010年
1期
27-29
,共3页
钱卫%杜学柯%黄冰%孟志秀
錢衛%杜學柯%黃冰%孟誌秀
전위%두학가%황빙%맹지수
布托啡诺%静脉自控镇痛%5-羟色胺%P物质%肾上腺素
佈託啡諾%靜脈自控鎮痛%5-羥色胺%P物質%腎上腺素
포탁배낙%정맥자공진통%5-간색알%P물질%신상선소
Butorphanol%Patient-controlled intravenous analgesia%5-Hydroxytryptamine%P substance%Epinephrine
目的 观察布托啡诺用于术后静脉自控镇痛对血清致痛物质5-羟色胺(5-HT)、P物质(PS)和肾上腺素(E)的影响.方法 全麻手术患者30例随机均分为布托啡诺组(B组)、吗啡组(M组)和对照组(D组).B组布托啡诺浓度0.006%,给药速率为0.0024 mg·kg~(-1)·min~(-1),负荷剂量为0.005 mg/kg,每次有效按压给药0.003 mg/kg,锁定间隔时间10 min.M组吗啡浓度为0.025%,给药速率为0.005 mg·kg~(-1)·min~(-1),负荷剂量为0.05 mg/kg,每次有效按压给药0.03 mg/kg,锁定间隔时间10 min.D组在患者需求时给予肌注吗啡10 mg.分别于麻醉诱导前(T_0)、术后12 h(T_1)、24 h(T_2)、36 h(T_3)、48 h(T_4)采集肘静脉血3 ml,采用酶联免疫吸附测定法测定血清中5-HT、PS和E水平.结果 B、M组T_1～T_4时5-HT、PS和E水平均低于D组(P<0.05).结论 布托啡诺静脉自控镇痛能抑制术后血清致痛物质5-HT、PS和E水平的升高,在一定程度上减弱痛觉信息传递,减轻机体应激反应.
目的 觀察佈託啡諾用于術後靜脈自控鎮痛對血清緻痛物質5-羥色胺(5-HT)、P物質(PS)和腎上腺素(E)的影響.方法 全痳手術患者30例隨機均分為佈託啡諾組(B組)、嗎啡組(M組)和對照組(D組).B組佈託啡諾濃度0.006%,給藥速率為0.0024 mg·kg~(-1)·min~(-1),負荷劑量為0.005 mg/kg,每次有效按壓給藥0.003 mg/kg,鎖定間隔時間10 min.M組嗎啡濃度為0.025%,給藥速率為0.005 mg·kg~(-1)·min~(-1),負荷劑量為0.05 mg/kg,每次有效按壓給藥0.03 mg/kg,鎖定間隔時間10 min.D組在患者需求時給予肌註嗎啡10 mg.分彆于痳醉誘導前(T_0)、術後12 h(T_1)、24 h(T_2)、36 h(T_3)、48 h(T_4)採集肘靜脈血3 ml,採用酶聯免疫吸附測定法測定血清中5-HT、PS和E水平.結果 B、M組T_1～T_4時5-HT、PS和E水平均低于D組(P<0.05).結論 佈託啡諾靜脈自控鎮痛能抑製術後血清緻痛物質5-HT、PS和E水平的升高,在一定程度上減弱痛覺信息傳遞,減輕機體應激反應.
목적 관찰포탁배낙용우술후정맥자공진통대혈청치통물질5-간색알(5-HT)、P물질(PS)화신상선소(E)적영향.방법 전마수술환자30례수궤균분위포탁배낙조(B조)、마배조(M조)화대조조(D조).B조포탁배낙농도0.006%,급약속솔위0.0024 mg·kg~(-1)·min~(-1),부하제량위0.005 mg/kg,매차유효안압급약0.003 mg/kg,쇄정간격시간10 min.M조마배농도위0.025%,급약속솔위0.005 mg·kg~(-1)·min~(-1),부하제량위0.05 mg/kg,매차유효안압급약0.03 mg/kg,쇄정간격시간10 min.D조재환자수구시급여기주마배10 mg.분별우마취유도전(T_0)、술후12 h(T_1)、24 h(T_2)、36 h(T_3)、48 h(T_4)채집주정맥혈3 ml,채용매련면역흡부측정법측정혈청중5-HT、PS화E수평.결과 B、M조T_1～T_4시5-HT、PS화E수평균저우D조(P<0.05).결론 포탁배낙정맥자공진통능억제술후혈청치통물질5-HT、PS화E수평적승고,재일정정도상감약통각신식전체,감경궤체응격반응.
Objective To study the effects of patient-controlled intravenous analgesia(PCIA) with butorphanol on plasma 5-Hydroxytryptamine (5-HT), P substance (PS), and epinephrine (E). Methods Thirty surgical patients were randomly divided into three groups with 10 cases each. PCIA with butorphanol was given in group B, with morphine in group D. The patients in group D were given morphine injection intramuscular when when needed. Venous blood samples were taken before anesthesia(T_0), at 12 h (T_1), 24 h (T_2), 36 h (T_3), and 48 h (T_4) during analgesia for detecting plasma 5-HT,PS and E by ELISA. Results Compared to group D, plasma levels of 5-HT,PS and E were significantly lower in groups of B and M at T_1 to T_4 (P (0. 05). Conclusion PCIA with butorphanol may attenuate the stress response to pain by suppressing the increase of 5-HT and PS and E in plasma.
