CAJ | 학술논문

目的探讨医院内感染不动杆菌肺炎的临床特点、危险因素及抗生素的敏感性.方法回顾性分析37例鲍曼不动杆菌肺炎患者的临床表现、痰细菌培养及药物敏感试验结果.结果 37例不动杆菌肺炎多发生在ICU病房、多数有侵袭性治疗、机械通气患者;亚胺培南、丁胺卡那霉素、哌拉西林/他唑巴坦是较为有效药物,对其他抗菌药物耐药率均较高;死亡5例,泛耐药菌株患者病死率41.7%,明显高于非泛耐药菌株患者(死亡2例,病死率8%).结论鲍曼不动杆菌是医院重要的多重耐药致病菌,宜根据药敏试验结果选用有效抗生素,对有危险因素者应及时行细菌培养加药敏试验.
목적 탐토의원내감염불동간균폐염적림상특점、위험인소급항생소적민감성.방법 회고성분석37례포만불동간균폐염환자적림상표현、담세균배양급약물민감시험결과.결과 37례불동간균폐염다발생재ICU병방、다수유침습성치료、궤계통기환자;아알배남、정알잡나매소、고랍서림/타서파탄시교위유효약물,대기타항균약물내약솔균교고;사망5례,범내약균주환자병사솔41.7%,명현고우비범내약균주환자(사망2례,병사솔8%).결론 포만불동간균시의원중요적다중내약치병균,의근거약민시험결과선용유효항생소,대유위험인소자응급시행세균배양가약민시험.
Objective To observe the clinical characteristics, risk factors, and sensitivity to antibiotics of nosocomial infections caused by acinetobacter baumannii. Methods Data were retrospectively collected from all isolated 37 strains acinetobacter. The clinical features, results of suptum culture and test of drug sensitivity were reviewed. Results The 37 acinetobacter baumannii strains mainly distributed in intensive care unit (ICU), most of them had the risk factors of receiving invasive treatment, mechanical ventilation, ect. The antibiotics imipenem, amikacin, pipercillin/tazobactam showed good efficacy for patients with acinetobacter infection, but other antibiotics had highly drug resistant rate. 5 were dead. The mortality of nosocomial infections caused by multi-drug resistant acinetobacter was 41.7%, which was much higher than the non-multi-drug resistant's (2 dead, the mortality was 8%). Conclusion Acinetobacter is one of the most important multi-drug resistant pathogen in nosocomial infections. Antimicrobial agents should be chosen according to antimicrobial susceptibility teat results. Patients who have the risk factors of nosocomial infections caused by acinetobacter should have suptum culture and antibiotic susceptibility studies as soon as possible.