中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2011年
2期
134-136
,共3页
刘庆斌%李海蓉%王玉华%王五一%刘晓波%王革%田淑彩%英殿双%于冰%王丽珍%冯福建
劉慶斌%李海蓉%王玉華%王五一%劉曉波%王革%田淑綵%英殿雙%于冰%王麗珍%馮福建
류경빈%리해용%왕옥화%왕오일%류효파%왕혁%전숙채%영전쌍%우빙%왕려진%풍복건
氟%铝%吸收%排泄
氟%鋁%吸收%排洩
불%려%흡수%배설
Fluoride%Aluminum%Absorption%Excretion
目的 观察砖茶中的氟、铝在人体内吸收、排泄和贮留的基本情况.方法 选择地方性氟中毒非病区的10名健康人作为观察对象,男、女各半,饮用砖茶(含氟量5.97 mg/L,含铝量7.53 mg/L).采用氟离子选择电极法和时序式电感耦合等离子体发射光谱法(ICP-AES)检测饮用砖茶前空腹与饮用砖茶后1.0、2.0、4.0、＞4.0～＜24.0 h及24.0 h后空腹尿含氟、铝量,计算24 h氟、铝总摄入量和排出量;采用氟离子选择电极法和电感耦合等离子体质谱法(ICP-MS)检测饮用砖茶前空腹与饮用砖茶后0.5、1.0、2.0、3.0 h及24.0 h后空腹血清含氟、铝量.结果 非病区健康人饮用砖茶前空腹与饮用砖茶后1.0、2.0、4.0、＞4.0～＜24.0 h及24.0 h后空腹尿含氟量分别为(0.50±0.14)、(2.14±0.90)、(1.57±0.93)、(2.43±1.49)、(1.91±0.69)、(0.58±0.20)mg/L,24 h尿氟排泄率为52.85%(4.64/8.78);尿含铝量分别为(0.35±0.15)、(0.65±0.37)、(0.50±0.25)、(0.52±0.21)、(0.50±0.23)、(0.46±0.27)mg/L,24 h尿铝排泄率为12.38%(1.37/11.07);饮用砖茶前空腹与饮用砖茶后0.5、1.0、2.0、3.0 h及24.0 h后空腹血清含氟量分别为(0.06±0.02)、(0.14±0.01)、(0.21±0.04)、(0.17±0.04)、(0.10±0.03)、(0.04±0.01)mg/L,血清含铝量分别为(0.30±0.05)、(0.27±0.01)、(0.30±0.12)、(0.34±0.19)、(0.30±0.10)、(0.27±0.09)mg/L.结论 砖茶中的氟较易被人体吸收、贮留和排泄,砖茶中的铝吸收较少,通过肾脏经尿排泄率相对较低,尿氟、铝尤其是空腹尿氟、铝水平较为稳定,可作为饮茶型氟铝联合中毒病情监测、预防试验效果判定指标,血清氟、铝水平可作为中毒指标.
目的 觀察磚茶中的氟、鋁在人體內吸收、排洩和貯留的基本情況.方法 選擇地方性氟中毒非病區的10名健康人作為觀察對象,男、女各半,飲用磚茶(含氟量5.97 mg/L,含鋁量7.53 mg/L).採用氟離子選擇電極法和時序式電感耦閤等離子體髮射光譜法(ICP-AES)檢測飲用磚茶前空腹與飲用磚茶後1.0、2.0、4.0、＞4.0～＜24.0 h及24.0 h後空腹尿含氟、鋁量,計算24 h氟、鋁總攝入量和排齣量;採用氟離子選擇電極法和電感耦閤等離子體質譜法(ICP-MS)檢測飲用磚茶前空腹與飲用磚茶後0.5、1.0、2.0、3.0 h及24.0 h後空腹血清含氟、鋁量.結果 非病區健康人飲用磚茶前空腹與飲用磚茶後1.0、2.0、4.0、＞4.0～＜24.0 h及24.0 h後空腹尿含氟量分彆為(0.50±0.14)、(2.14±0.90)、(1.57±0.93)、(2.43±1.49)、(1.91±0.69)、(0.58±0.20)mg/L,24 h尿氟排洩率為52.85%(4.64/8.78);尿含鋁量分彆為(0.35±0.15)、(0.65±0.37)、(0.50±0.25)、(0.52±0.21)、(0.50±0.23)、(0.46±0.27)mg/L,24 h尿鋁排洩率為12.38%(1.37/11.07);飲用磚茶前空腹與飲用磚茶後0.5、1.0、2.0、3.0 h及24.0 h後空腹血清含氟量分彆為(0.06±0.02)、(0.14±0.01)、(0.21±0.04)、(0.17±0.04)、(0.10±0.03)、(0.04±0.01)mg/L,血清含鋁量分彆為(0.30±0.05)、(0.27±0.01)、(0.30±0.12)、(0.34±0.19)、(0.30±0.10)、(0.27±0.09)mg/L.結論 磚茶中的氟較易被人體吸收、貯留和排洩,磚茶中的鋁吸收較少,通過腎髒經尿排洩率相對較低,尿氟、鋁尤其是空腹尿氟、鋁水平較為穩定,可作為飲茶型氟鋁聯閤中毒病情鑑測、預防試驗效果判定指標,血清氟、鋁水平可作為中毒指標.
목적 관찰전다중적불、려재인체내흡수、배설화저류적기본정황.방법 선택지방성불중독비병구적10명건강인작위관찰대상,남、녀각반,음용전다(함불량5.97 mg/L,함려량7.53 mg/L).채용불리자선택전겁법화시서식전감우합등리자체발사광보법(ICP-AES)검측음용전다전공복여음용전다후1.0、2.0、4.0、＞4.0～＜24.0 h급24.0 h후공복뇨함불、려량,계산24 h불、려총섭입량화배출량;채용불리자선택전겁법화전감우합등리자체질보법(ICP-MS)검측음용전다전공복여음용전다후0.5、1.0、2.0、3.0 h급24.0 h후공복혈청함불、려량.결과 비병구건강인음용전다전공복여음용전다후1.0、2.0、4.0、＞4.0～＜24.0 h급24.0 h후공복뇨함불량분별위(0.50±0.14)、(2.14±0.90)、(1.57±0.93)、(2.43±1.49)、(1.91±0.69)、(0.58±0.20)mg/L,24 h뇨불배설솔위52.85%(4.64/8.78);뇨함려량분별위(0.35±0.15)、(0.65±0.37)、(0.50±0.25)、(0.52±0.21)、(0.50±0.23)、(0.46±0.27)mg/L,24 h뇨려배설솔위12.38%(1.37/11.07);음용전다전공복여음용전다후0.5、1.0、2.0、3.0 h급24.0 h후공복혈청함불량분별위(0.06±0.02)、(0.14±0.01)、(0.21±0.04)、(0.17±0.04)、(0.10±0.03)、(0.04±0.01)mg/L,혈청함려량분별위(0.30±0.05)、(0.27±0.01)、(0.30±0.12)、(0.34±0.19)、(0.30±0.10)、(0.27±0.09)mg/L.결론 전다중적불교역피인체흡수、저류화배설,전다중적려흡수교소,통과신장경뇨배설솔상대교저,뇨불、려우기시공복뇨불、려수평교위은정,가작위음다형불려연합중독병정감측、예방시험효과판정지표,혈청불、려수평가작위중독지표.
Objective To observe the absorption, excretion and retention of fluoride and aluminum after drinking brick tea in healthy adults. Methods The study was conducted in ten healthy volunteers by drinking brick tea solution in which the fluoride and aluminum concentrations were 5.97, 7.53 mg/L, respectively. The concentrations of fluoride and aluminum were determined in serum samples collected before and at 0.5,1.0,2.0,3.0,and 24.0 h, and in urine samples collected before and during the periods 1.0,2.0,4.0, ＞ 4.0 - ＜ 24.0 h and 24 h after drinking brick tea solution by ion-selective electrode, inductively coupled plasma atomic emission spectrometry (ICP-AES) and inductively coupled plasma atomic mess spectrometry. The total amounts of intake and excretion of fluoride and aluminum in healthy volunteers during 24.0 h were calculated from their corresponding fluoride and aluminum ingesting from brick tea and excreting from urine. Results Before and during the periods 1.0,2.0,4.0,＞ 4.0 - ＜ 24.0 h and 24.0 h after drinking brick tea solution, the urinary fluoride concentrations were (0.50 ±0.14), (2.14 ± 0.90), (1.57 ± 0.93), (2.43 ± 1.49), (1.91 ± 0.69), (0.58 ± 0.20)mg/L, respectively, and the aluminum concentrations in the urine samples were (0.35 ± 0.15), (0.65 ± 0.37), (0.50 ± 0.25), (0.52 ± 0.21 ),(0.50 ± 0.23), (0,46 ± 0.27)mg/L, respectively; the 24.0 h excreting rates of fluoride and aluminum from urine were 52.90%(4.64/8.77) and 12.38% (1.37/11.07), respectively. The fluoride concentrations in serum samples collected before and at 0.5,1.0,2.0,3.0,24.0 h after drinking brick tea solution were (0.06 ± 0.02), (0.14 ± 0.01 ), (0.21 ±0.04), (0.17 ± 0.04), (0.10 ± 0.03), (0.04 ± 0.01 )mg/L, respectively, and aluminum in those were (0.30 ± 0.05),(0.27 ± 0.01 ), (0.30 ± 0.12), (0.34 ± 0.19), (0.30 ± 0.10), (0.27 ± 0.09)mg/L, respectively. Conclusions Fluoride in brick tea is easyly to be absorbed and excreted through kidney, and the kidney excretory capacity of aluminum in brick tea is limited. Levels of fluoride and aluminum in urine could be taken as the indicators for monitoring the prevalent extent and evaluating preventive experiment's effect on the brick tea fluoride-aluminum toxicity; and fasting serum fluoride and aluminum levels could be taken as indicators for estimating the toxic condition of the brick tea fluoride-aluminum toxicity.
