CAJ | 학술논문

目的采用基于体素的形态学分析(VBM)方法探讨唇腭裂患儿脑结构特征.方法在1.5 T磁共振扫描仪上采集数据,运用优化VBM方法比较10例唇腭裂患儿及10例正常对照婴幼儿的脑结构.对2组婴幼儿的灰白质密度和体积进行基于体素的双样本t检验,对比结果采用国际通用的统计参数图(SPM)表示,分析唇腭裂患儿大脑灰质密度及体积异常区域分布特征及其临床意义.结果唇腭裂组的灰质体积在属于额上回的双侧前额叶内侧显著低于正常对照组(差异团簇体积体素个数:5220、4871,团簇水平校正后P值均小于0.05),灰质密度在左侧颞上回显著高于正常对照组(体素水平校正后P值小于0.05),脑白质密度和体积均无显著性的差异.结论唇腭裂患儿与听觉及认知有关的皮层可能异于正常婴幼儿,应对此类患儿进行中枢听觉处理功能及认知功能的早期检查和早期干预.
목적 채용기우체소적형태학분석(VBM)방법탐토진악렬환인뇌결구특정.방법 재1.5 T자공진소묘의상채집수거,운용우화VBM방법비교10례진악렬환인급10례정상대조영유인적뇌결구.대2조영유인적회백질밀도화체적진행기우체소적쌍양본t검험,대비결과채용국제통용적통계삼수도(SPM)표시,분석진악렬환인대뇌회질밀도급체적이상구역분포특정급기림상의의.결과 진악렬조적회질체적재속우액상회적쌍측전액협내측현저저우정상대조조(차이단족체적체소개수:5220、4871,단족수평교정후P치균소우0.05),회질밀도재좌측섭상회현저고우정상대조조(체소수평교정후P치소우0.05),뇌백질밀도화체적균무현저성적차이.결론 진악렬환인여은각급인지유관적피층가능이우정상영유인,응대차류환인진행중추은각처리공능급인지공능적조기검사화조기간예.
Objective To investigate the structural characteristics of brain in children with cleft lip and/or palate by voxel- based morphometry (VBM). Methods Optimized VBM (OVBM) was used to compare the data acquired on a 1.5 T magnetic resonance scanner from ten cases of cleft lip and/or palate patients and from ten normal controls. The density and volume of gray and white matters in two groups of young children were examined with two-sample t-test and displayed with the internationally accepted statistical parametric mapping (SPM). Abnormal distribution of gray and white matters in children with cleft lip and/or palate as clinically relevant was analyzed. Results Compared with normal controls, significantly smaller volume in gray matter of bilateral medial prefrontal cortex belonging to the superior frontal gyrus was noted in children with cleft lip and/or palate, (voxels of clusters with varied volume: 5220 and 4871,adjusted P＜0.05 at cluster level), as was significantly greater density in gray matter of the left superior temporal gyrus (adjusted P＜0.05 at voxel level). No significant difference in density or volume of white matter was observed between groups. Conclusion Difference may exist in cortex responsible for hearing and cognition between children with cleft lip and/or palate and normal children, suggesting the necessity for such children to be early examined and intervened for central auditory processing and cognitive functions.