CAJ | 학술논문

对哮喘急性发作期60例患者治疗前测定呼出气一氧化氮(FeNO)、血降钙素原(PCT)、CRP水平,并进行痰细菌培养；根据痰培养结果将患者分为有细菌感染组(A组)、无细菌感染组(B组).临床缓解期时重复上述指标检测.急性发作期时患者FeNO值显著高于临床缓解期(P＜0.05),A组FeNO与B组相比差异无统计学意义(P＞0.05)；急性发作期,A组血PCT、CRP显著高于B组(P均＜0.05)；A组临床缓解期血PCT、CRP显著低于急性发作期(P均＜0.05)；B组临床缓解期血PCT、CRP与急性发作期比较,差异无统计学意义(P＞0.05).临床缓解期,A、B两组血PCT、CRP比较差异亦无统计学意义(P＞0.05).
대효천급성발작기60례환자치료전측정호출기일양화담(FeNO)、혈강개소원(PCT)、CRP수평,병진행담세균배양；근거담배양결과장환자분위유세균감염조(A조)、무세균감염조(B조).림상완해기시중복상술지표검측.급성발작기시환자FeNO치현저고우림상완해기(P＜0.05),A조FeNO여B조상비차이무통계학의의(P＞0.05)；급성발작기,A조혈PCT、CRP현저고우B조(P균＜0.05)；A조림상완해기혈PCT、CRP현저저우급성발작기(P균＜0.05)；B조림상완해기혈PCT、CRP여급성발작기비교,차이무통계학의의(P＞0.05).림상완해기,A、B량조혈PCT、CRP비교차이역무통계학의의(P＞0.05).
A total of 60 patients with an acute attack of asthma were studied.On presentation,fractional exhaled nitric oxide (FeNO) and the serum concentrations of procalcitonin (PCT) and C-reactive protein (CRP) were measured.And sputum culture was also performed.The patients were re-evaluated while returning to their clinical remission states.They were classified into 2 groups:patients with bacterial infection (group A) and those with nonbacterial infection (group B).The levels of FeNO were significantly higher in patients with acute exacerbation than those in remission.No difference existed between groups A and B ( P ＞ 0.05 ).The levels of PCT and CRP of group A with acute exacerbation were significantly higher than those of group B( all P ＜0.05).While in remission,the levels of PCT and CRP decreased significantly in group A ( P ＜ 0.05 ) ; But compared with exacerbation,the levels of PCT and CRP showed no change in group B (P ＞0.05).And no differences existed between two groups while in remission (P ＞ 0.05 ).An elevation of FeNO indicates the acute exacerbation of asthma.And the increased serum levels of PCT and CRP are associated with bacterial infection.