中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2008年
4期
239-243
,共5页
受体,骨化三醇%多态性,单限制性片段长度%骨密度%用力
受體,骨化三醇%多態性,單限製性片段長度%骨密度%用力
수체,골화삼순%다태성,단한제성편단장도%골밀도%용력
Receptor,calcitriol%Polymorphism,restriction fragment length%Bone density%Exertion
目的 探讨维生素D受体(VDR)基因起始密码子(Fok I位点)多态性与体力活动对青春期女童骨量增长的交互作用.方法 选择228名9～11.5岁未月经初潮的健康女童进行2年追踪,应用双能X线骨密度仪检测对象追踪前后全身、左侧近端股骨(包括股骨颈、大转子、粗隆间和华氏三角区)和L1～L4腰椎骨密度,应用PCR-RFLP技术检测VDR基因Fok I位点多态性.结果 本次研究的有效观察人数为176名.Fok I位点多态性与骨密度(BMD)2年增长率没有关联.在低体力活动水平(<1197 kJ/d)时,FF基因型女童左侧近端股骨骨密度(THBMD)和股骨颈骨密度(FNBMD)增长率低于Ff+ff基因型女童,差异有统计学意义;体力活动与THBMD和FNBMD增长率有关联,但仅限于FF基因型女童.结论 VDR基因Fok I多态性与体力活动水平对青春期女童骨量增长存在交互作用,低体力活动水平的FF基因型女童可能是骨量增长较低的危险人群,体力活动能促进FF基因型女童骨量增长.
目的 探討維生素D受體(VDR)基因起始密碼子(Fok I位點)多態性與體力活動對青春期女童骨量增長的交互作用.方法 選擇228名9～11.5歲未月經初潮的健康女童進行2年追蹤,應用雙能X線骨密度儀檢測對象追蹤前後全身、左側近耑股骨(包括股骨頸、大轉子、粗隆間和華氏三角區)和L1～L4腰椎骨密度,應用PCR-RFLP技術檢測VDR基因Fok I位點多態性.結果 本次研究的有效觀察人數為176名.Fok I位點多態性與骨密度(BMD)2年增長率沒有關聯.在低體力活動水平(<1197 kJ/d)時,FF基因型女童左側近耑股骨骨密度(THBMD)和股骨頸骨密度(FNBMD)增長率低于Ff+ff基因型女童,差異有統計學意義;體力活動與THBMD和FNBMD增長率有關聯,但僅限于FF基因型女童.結論 VDR基因Fok I多態性與體力活動水平對青春期女童骨量增長存在交互作用,低體力活動水平的FF基因型女童可能是骨量增長較低的危險人群,體力活動能促進FF基因型女童骨量增長.
목적 탐토유생소D수체(VDR)기인기시밀마자(Fok I위점)다태성여체력활동대청춘기녀동골량증장적교호작용.방법 선택228명9～11.5세미월경초조적건강녀동진행2년추종,응용쌍능X선골밀도의검측대상추종전후전신、좌측근단고골(포괄고골경、대전자、조륭간화화씨삼각구)화L1～L4요추골밀도,응용PCR-RFLP기술검측VDR기인Fok I위점다태성.결과 본차연구적유효관찰인수위176명.Fok I위점다태성여골밀도(BMD)2년증장솔몰유관련.재저체력활동수평(<1197 kJ/d)시,FF기인형녀동좌측근단고골골밀도(THBMD)화고골경골밀도(FNBMD)증장솔저우Ff+ff기인형녀동,차이유통계학의의;체력활동여THBMD화FNBMD증장솔유관련,단부한우FF기인형녀동.결론 VDR기인Fok I다태성여체력활동수평대청춘기녀동골량증장존재교호작용,저체력활동수평적FF기인형녀동가능시골량증장교저적위험인군,체력활동능촉진FF기인형녀동골량증장.
Objective To investigate the association between the polymorphism of vitamin D receptor (VDR) gene start codon (Fok I) and bone mass accrual,and assessing if such an association could be modified bv physical activity in Chinese adolescent girls.Methods A total of 228 premenrche Chinese girls (9-11.5 years old) were recruited for 2-year study. Bone mineral densities (BMD) at the total body,total left hip (including femoral neck,trochanter,intertrochanter and Ward's triangle area) and lumbar spine (L1-L4)were measured by dual energy X-ray absorptiometry.The Fok I polymorphism of VDR gene was detected with PCR-RFLP.Results There remained 176 available subjects in our cohort when 2-year study was completed. No significant association was observed between Fok I polymorphism of VDR gene and percentage change in BMD at all sites. Girls with FF genotype had lower percentage change in total left hip BMD (THBMD) and femoral neck BMD (FNBMD) than girls with Ff+ff genotype only in low physical activity (<1 197 kJ/d),and physical activity was associated with percentage change in THBMD and FNBMD only in FF genotype group.Conclusion The Fok I polymorphism of VDR gene should have significant interaction effect with physical activity on bone mass accrual in Chinese adolescent girls.Girls with FF genotype in low physical activity would be the potential risk population for low bone mass accrual,and high physical activity would be of benefit to gain higher bone mass accrual for girls with FF genotype.
