CAJ | 학술논문

上皮-间质转化(EMT)使原发癌细胞获得间质特征,并且在转移部位上皮再生形成继发性肿瘤.该过程参与乳腺癌的浸润和转移,有可能影响疗效.乳腺癌细胞的一系列标记蛋白可监测转录调节和表观遗传调控引起的细胞学行为的特征性改变,并能够提供预测依据和治疗靶点.
상피-간질전화(EMT)사원발암세포획득간질특정,병차재전이부위상피재생형성계발성종류.해과정삼여유선암적침윤화전이,유가능영향료효.유선암세포적일계렬표기단백가감측전록조절화표관유전조공인기적세포학행위적특정성개변,병능구제공예측의거화치료파점.
Epithelial-mesenchymal transition cause primary carcinoma cells to acquire mesenchymal features and re-epithelialize to form a secondary mass at a metastatic site. Such plasticity has implications in the progression of breast carcinoma to metastasis, and will likely influence cancer's response to therapy. The transcriptional and epigenetic regulation that underlie the development of breast cancer and result in characteristic changes in cell behavior can be monitored using an array of marker proteins, providing the potential for emergent prognostic and therapeutic targeting.