CAJ | 학술논문

目的分析三阴性乳腺癌的临床病理特征及与预后的关系. 方法回顾性分析2002年1月-2007年2月北京通州妇幼保健院收治的乳腺癌患者196例,进行免疫组织化学法测定Her-2、ER、PR蛋白表达,并分为两组,一组为三阴性(triple-negative)乳腺癌,即Her2(-),ER(-),PR(-),另一组为非三阴性乳腺癌.分析三阴性和非三阴性乳腺癌的临床病理特征,比较三阴性乳腺癌患者术后的3年无瘤生存率. 结果三阴性乳腺癌在所有患者中所占比例为13.27%(26/196),其肿瘤大小情况、组织学Ⅲ级的比例高于非三阴性乳腺癌(P＜0.05).三阴性乳腺癌和非三阴性乳腺癌3年无瘤生存率分别为84.62%(22/26)和92.94%(158/170). 结论三阴性乳腺癌较非三阴性乳腺癌易发生局部复发和远处转移,预后差.
목적 분석삼음성유선암적림상병리특정급여예후적관계. 방법 회고성분석2002년1월-2007년2월북경통주부유보건원수치적유선암환자196례,진행면역조직화학법측정Her-2、ER、PR단백표체,병분위량조,일조위삼음성(triple-negative)유선암,즉Her2(-),ER(-),PR(-),령일조위비삼음성유선암.분석삼음성화비삼음성유선암적림상병리특정,비교삼음성유선암환자술후적3년무류생존솔. 결과 삼음성유선암재소유환자중소점비례위13.27%(26/196),기종류대소정황、조직학Ⅲ급적비례고우비삼음성유선암(P＜0.05).삼음성유선암화비삼음성유선암3년무류생존솔분별위84.62%(22/26)화92.94%(158/170). 결론 삼음성유선암교비삼음성유선암역발생국부복발화원처전이,예후차.
Objective To analyze the relationship of clinicopathologic Features and prognosis of triple negative breast cancer. Methods A total of 196 cases with operable breast cancer received in our hospital between January 2002 and February 2007 were analyzed. We used immunohistochemistry to determine Her2, ER, and PR status. The patients were divided into the triple negative breast cancer group (ER negative,PR negative, and Her-2 negative)and the non-triple negative breast cancer group. The clinicopathologic features of the two groups were compared. The 3-year disease-free survival (DFS) was analyzed. Results Of the 196 patients, 13.27% (26/196) had triple negative breast cancer. The percentage of cases with tumor exceeded 5 cm or grade Ⅲ was higher in the triple negative group than in the non-triple negative group (P ＜ 0.05 ). No significant difference was found in other clinicopathologic features between the two groups.The 3-year DFS was 84.62% (22/26) in the triple negative group and 92.94% ( 158/170)in the non-triple negative group. Conclusion Compared with non triple negative breast cancer, triple negative breast cancer has an increased possibility of local recurrence or distant metastasis,leading to a poorer prognosis.