国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2009年
2期
104-106
,共3页
骨骼肌%糖代谢%高血糖%肌病
骨骼肌%糖代謝%高血糖%肌病
골격기%당대사%고혈당%기병
Skeletal muscle%Glucose metabolism%Hyperglycemia%Muscular diseases
骨骼肌是体内胰岛素刺激下摄取葡萄糖的主要组织,在糖代谢平衡中发挥着重要的作用.病理状态下的骨骼肌这种代谢调节能力下降.肌糖原及循环中葡萄糖是维持骨骼肌细胞正常代谢及功能的主要物质.糖代谢紊乱尤其是高血糖对骨骼肌的代谢、结构及功能等都有明显影响,包括高血糖导致骨骼肌胰岛素抵抗、对肌糖原代谢的影响、肌萎缩以及血管异常等,肌组织病变反过来又影响代谢的控制,使病情加重.
骨骼肌是體內胰島素刺激下攝取葡萄糖的主要組織,在糖代謝平衡中髮揮著重要的作用.病理狀態下的骨骼肌這種代謝調節能力下降.肌糖原及循環中葡萄糖是維持骨骼肌細胞正常代謝及功能的主要物質.糖代謝紊亂尤其是高血糖對骨骼肌的代謝、結構及功能等都有明顯影響,包括高血糖導緻骨骼肌胰島素牴抗、對肌糖原代謝的影響、肌萎縮以及血管異常等,肌組織病變反過來又影響代謝的控製,使病情加重.
골격기시체내이도소자격하섭취포도당적주요조직,재당대사평형중발휘착중요적작용.병리상태하적골격기저충대사조절능력하강.기당원급순배중포도당시유지골격기세포정상대사급공능적주요물질.당대사문란우기시고혈당대골격기적대사、결구급공능등도유명현영향,포괄고혈당도치골격기이도소저항、대기당원대사적영향、기위축이급혈관이상등,기조직병변반과래우영향대사적공제,사병정가중.
Skeletal muscle is the principal site of glucose uptake under insulin-stimulated conditions,and it plays an important role in the glucose homeostasis. Under pathological state, the regulation of skeletal muscle on glucose metabolism is decreased. Muscle glycogen and the circulation glucose are essential for the physiological metabolism and function of skeletal muscle. The glucose metabolic disturbance, especially hyperglycemia, has profound impact on the skeletal muscle with regard to dysfunction, metabolic disturbance and structural changes, including insulin resistance, muscle glycogen metabolic disturbance, myatrophy and vascular abnormality. Myopathy may affect metabolism in turn,which may worsen the pathogenetic condition.