CAJ | 학술논문

目的探讨2型糖尿病患者非糖尿病正常体重一级亲属脂联素水平变化及脂联素与胰岛素敏感性和颈动脉内膜中层厚度(IMT)之间的关系.方法入选2型糖尿病非糖尿病正常体重一级亲属53名和对照组37名,入组时检测了脂联素、血脂、血糖、血压及空腹胰岛素水平.用高频B超检测IMT及内皮依赖性血管舒张功能(EDVD).采用稳态模式(HOMA)评价胰岛素抵抗(HOMA-IR)和评价胰岛β细胞功能(HOMA-β).一级亲属组29名和对照组20名完成了5年随访.结果基线时一级亲属组血浆脂联素水平明显低于对照组[(10.06±5.79)对(14.43±7.91)mg/L,P<0.05].5年后一级亲属组脂联素水平降低24.0%(P<0.05),对照组脂联素水平降低36.7%(P<0.05).一级亲属组脂联素与腰臀比(r=-0.397)、空腹血糖(r=-0.373)、IMT(r=-0.372)和HOMA-IR(r=-0.40)负相关(均P<0.05).校正相关因素后,多元逐步回归分析显示一级亲属组脂联素与年龄,高密度脂蛋白胆固醇(HDL-C),IMT独立相关.对照组脂联素与低密度脂蛋白胆周醇(LDL-C)和IMT独立相关.结论 5年后一级亲属组和对照组脂联素水平均明显降低,脂联素降低可能与IMT增加相关.
목적탐토2형당뇨병환자비당뇨병정상체중일급친속지련소수평변화급지련소여이도소민감성화경동맥내막중층후도(IMT)지간적관계.방법입선2형당뇨병비당뇨병정상체중일급친속53명화대조조37명,입조시검측료지련소、혈지、혈당、혈압급공복이도소수평.용고빈B초검측IMT급내피의뢰성혈관서장공능(EDVD).채용은태모식(HOMA)평개이도소저항(HOMA-IR)화평개이도β세포공능(HOMA-β).일급친속조29명화대조조20명완성료5년수방.결과기선시일급친속조혈장지련소수평명현저우대조조[(10.06±5.79)대(14.43±7.91)mg/L,P<0.05].5년후일급친속조지련소수평강저24.0%(P<0.05),대조조지련소수평강저36.7%(P<0.05).일급친속조지련소여요둔비(r=-0.397)、공복혈당(r=-0.373)、IMT(r=-0.372)화HOMA-IR(r=-0.40)부상관(균P<0.05).교정상관인소후,다원축보회귀분석현시일급친속조지련소여년령,고밀도지단백담고순(HDL-C),IMT독립상관.대조조지련소여저밀도지단백담주순(LDL-C)화IMT독립상관.결론 5년후일급친속조화대조조지련소수평균명현강저,지련소강저가능여IMT증가상관.
Objective To investigate the adiponectin levels in non-obese first-degree relatives (FDR)of type 2 diabetic subjects and its relation to insulin sensitivity and the intima-media thickness of the common carotid artery (IMT) during 5-year follow-up. Methods Fifty-three FDR subjects and 37 control subjects who were free of type 2 diabetes were enrolled. Plasma adipenectin, lipid profile, blood glucose, fasting insulin, and blood pressure were determined at baseline and after 5-year follow-up. IMT and endothelial-dependent vasodilation (EDVD) were measured by high-resolution B-mode ultrasound imaging. Homeostasis model assessment was used to evaluate insulin resistance (HOMA-IR)and β-cell function (HOMA-β). 29 FDR subjects and 20 control subjects completed the follow-up. Results Comparing with the control, plasma adiponectin levels in non-obese FDR subjects were lower at baseline [(10.06±5.79)vs (14.43±7.91) mg/L, P< 0.05]. Plasma adiponectin were decreased 24.0% in non-obese FDR and 36.7% in control duning 5 year follow-up (both P<0.05). Adiponectin levels were negatively correlated with waist-to-hip ratio (r = -0. 397), fasting blood glucose (r = -0. 373), IMT (r = -0. 372), and HOMA-IR (r=-0. 40)in the non-obese FDR. After adjusting other relevant risk factors,adiponectin was associated with age, high-density lipoprotein-cholesterol, and IMT in multiple regression analyses in non-obese FDR group. In the control group, a similar analysis revealed that low-density lipoprotein-cholesterol and IMT explained 25% of the variability in the adiponectin concentration. Conclusion Plasma adiponectin levels were decreased after 5 years in both non-obese FDR and control subjects. Decreased adiponectin level may be related to IMT increment.