国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2010年
4期
273-276
,共4页
IL-17%Th17细胞%幽门螺杆菌%胃疾病
IL-17%Th17細胞%幽門螺桿菌%胃疾病
IL-17%Th17세포%유문라간균%위질병
IL-17%Th cells%Helicobacter pylori%Gastric disease
幽门螺杆菌(Hp)是导致人类发生慢性活动性胃炎、消化性溃疡的主要病原菌,并且与胃腺癌、胃黏膜相关淋巴组织淋巴瘤的发生也密切相关.Hp诱导产生的白细胞介素-17(IL-17)作为第二信使招致粒细胞在局部聚集,是引起胃部炎症反应以及进一步病理损害的重要调节因子.在Hp感染性胃疾病中,胃粘膜中的IL-17蛋白表达明显增加.
幽門螺桿菌(Hp)是導緻人類髮生慢性活動性胃炎、消化性潰瘍的主要病原菌,併且與胃腺癌、胃黏膜相關淋巴組織淋巴瘤的髮生也密切相關.Hp誘導產生的白細胞介素-17(IL-17)作為第二信使招緻粒細胞在跼部聚集,是引起胃部炎癥反應以及進一步病理損害的重要調節因子.在Hp感染性胃疾病中,胃粘膜中的IL-17蛋白錶達明顯增加.
유문라간균(Hp)시도치인류발생만성활동성위염、소화성궤양적주요병원균,병차여위선암、위점막상관림파조직림파류적발생야밀절상관.Hp유도산생적백세포개소-17(IL-17)작위제이신사초치립세포재국부취집,시인기위부염증반응이급진일보병리손해적중요조절인자.재Hp감염성위질병중,위점막중적IL-17단백표체명현증가.
Helicobacter pylori(H.pylori or Hp)is the major pathogen which causes human chronic active gastritis and peptic ulcer.Hp is closely related to gastric adenocarcinoma,gastric mucosa-associated lymphoid tissue lymphoma.As the second messenger,IL-17 induced by Hp aggregated of granulocyte cells in parts of stomach.IL-17 is an important regulator which cayses stomach inflammation and further pathological damages.The expression of IL-17 protein in the gastric mucosa increased significantly in patients with gastric diseases caused by Hp.
