CAJ | 학술논문

目的探讨热毒宁注射液治疗儿童手足口病的疗效.方法将1139例普通型手足口病患儿完全随机分为2组,研究组(519例),对照组(620例),分别采用热毒宁0.6ml/( kg·d)与利巴韦林10～15ml/(kg·d)治疗3～5d,比较2组患儿的退热时间、皮疹消退时间、治疗时间的差异及转归.结果研究组总有效率高于对照组(98.5％比98.2％);研究组退热时间、皮疹消退时间、治疗时间均少于对照组[分别为(1.8±0.6)d比(2.4±0.5)d、(2.6±0.7)d比(3.3±0.6)d、(3.5±0.5)d比(3.9±0.4)d,均P＜0.01].研究组未发现不良反应,对照组有13例一过性白细胞下降.结论热毒宁治疗儿童手足口病疗效优于利巴韦林,且安全无明显不良反应.
목적 탐토열독저주사액치료인동수족구병적료효.방법 장1139례보통형수족구병환인완전수궤분위2조,연구조(519례),대조조(620례),분별채용열독저0.6ml/( kg·d)여리파위림10～15ml/(kg·d)치료3～5d,비교2조환인적퇴열시간、피진소퇴시간、치료시간적차이급전귀.결과 연구조총유효솔고우대조조(98.5％비98.2％);연구조퇴열시간、피진소퇴시간、치료시간균소우대조조[분별위(1.8±0.6)d비(2.4±0.5)d、(2.6±0.7)d비(3.3±0.6)d、(3.5±0.5)d비(3.9±0.4)d,균P＜0.01].연구조미발현불량반응,대조조유13례일과성백세포하강.결론 열독저치료인동수족구병료효우우리파위림,차안전무명현불량반응.
Objective To explore the efficacy of treatment on foot-hand-and-mouth with Reduning.Methods As a randomized controlled study,1139 cases of hand,foot and mouth disease children were randomly divided into 2 groups.519 cases were classified as study group,using Reduning for three to five days,620 cases were classified as control group,using ribavirin for three to five days.The cooling time,rash subside time,the differences of treatment time and outcomes of the two drugs were compared between the two groups.Results The overall effective rate of the Reduning group was 98.5％,significantly higher than that of the Ribavirin group(98.2％);the fever clearance time of the Reduning group was(1.8±0.6) d,significantly leas than that of the Ribavirin group(2.4±0.5)d(P ＜0.01);the rash subsided average of the Reduning group(2.6±0.7)d was significantly shorter than that of the Ribavirin group(3.3±0.6) d(P ＜ 0.01);the average duration treatment of the Reduning group was(3.5±0.5)d,significantly less than that of the Ribavirin group(3.9±0.4)d(P＜0.01).Reduning group had no adverse reactions but the Ribavirin group had 13 cases of transient leukopenia.Conclusions The Reduning is more effective than ribavirin in the treatment of children with hand,foot and mouth disease.It is a safe therapy.