CAJ | 학술논문

目的探讨膀胱尿路上皮癌与Fas介导的血T淋巴细胞凋亡的关系.方法应用流式细胞仪检测52例膀胱癌患者和37例健康对照者外周血CD4Fas、CD8Fas阳性T细胞.结果膀胱癌患者外周血CIM、CD8Fas阳性T细胞分别为(20.74±9.02)%、(7.51±5.93)%,对照组分别为(15.68±5.58)%、(4.27±3.08)%,肿瘤组较对照组明显增加(P<0.01).浸润组CD8Fas阳性T细胞数为(5.83±3.95)%,表浅组为(5.83±3.95)%,浸润组较表浅组明显降低(P<0.05).复发组CD4、CD8Fas阳性T细胞与初发组比较筹异无统计学意义(P>0.05).结论血T淋巴细胞Fas表达的异常可能在膀胱癌的发生发展中起重要的作用.
목적 탐토방광뇨로상피암여Fas개도적혈T림파세포조망적관계.방법 응용류식세포의검측52례방광암환자화37례건강대조자외주혈CD4Fas、CD8Fas양성T세포.결과 방광암환자외주혈CIM、CD8Fas양성T세포분별위(20.74±9.02)%、(7.51±5.93)%,대조조분별위(15.68±5.58)%、(4.27±3.08)%,종류조교대조조명현증가(P<0.01).침윤조CD8Fas양성T세포수위(5.83±3.95)%,표천조위(5.83±3.95)%,침윤조교표천조명현강저(P<0.05).복발조CD4、CD8Fas양성T세포여초발조비교주이무통계학의의(P>0.05).결론 혈T림파세포Fas표체적이상가능재방광암적발생발전중기중요적작용.
Objective To investigate the relationship between the Fas expression in peripheral blood T cells and bladder transitional cell carcinoma (TCC). Methods The Fas expression in peripheral blood T cells of 52 patients with TCC and 37 healthy people was detected by flowcytometry. The Fas-posi-tive rate was compared by t test between two designed groups. Results The Fas expression in CD4+ [(20.74±9.02)%] and CD8+[ (7.51±5.93 )% ] was increased in TCC patients as compared with controls ( P < 0. 01 ). Fas-positive CD8+ ceils were reduced in invasive TCC as compared with superficial TCC [ ( 5. 83±3.95 ) % vs ( 5. 83±3.95 ) %, P < 0.05 ], but there was no difference between primary and recurrent cases ( P > 0.05 ). Conclusion The abnormal Fas expression in peripheral blood T cells may play an important role in the development and progression of TCC.