中华胸心血管外科杂志
中華胸心血管外科雜誌
중화흉심혈관외과잡지
Chinese Journal of Thoracic and Cardiovascular Surgery
2008年
3期
178-179
,共2页
刘海波%张志孟%张光磊%杨顺章%吴伟平
劉海波%張誌孟%張光磊%楊順章%吳偉平
류해파%장지맹%장광뢰%양순장%오위평
心肺转流术%肿瘤坏死因子α%白细胞介素-8%白细胞介素-10%一氧化氮
心肺轉流術%腫瘤壞死因子α%白細胞介素-8%白細胞介素-10%一氧化氮
심폐전류술%종류배사인자α%백세포개소-8%백세포개소-10%일양화담
Cardiopulmonary Bypass Tumor necrosis factor-α Interleukin-8 Interleukin-10 Nitric oxide
目的 探讨吸入一氧化氮(NO)对婴幼儿体外循环手术中细胞因子变化的影响及意义.方法 室间隔缺损的婴幼儿30例随机分为对照组和NO组,NO组在体外循环期间吸人40×10-6NO直至关胸.在体外循环前、主动脉开放后1、3、5、10 min分别取右上肺静脉血和右心房血测定TNF-α、IL-8、IL-10.结果 NO组IL-10水平较对照组增高(P<0.01),TNF-α、IL-8则较对照组明显降低(P<0.05).结论 NO能抑制炎症性细胞因子,促进抗炎细胞因子的活性,故可减轻体外循环并发症.
目的 探討吸入一氧化氮(NO)對嬰幼兒體外循環手術中細胞因子變化的影響及意義.方法 室間隔缺損的嬰幼兒30例隨機分為對照組和NO組,NO組在體外循環期間吸人40×10-6NO直至關胸.在體外循環前、主動脈開放後1、3、5、10 min分彆取右上肺靜脈血和右心房血測定TNF-α、IL-8、IL-10.結果 NO組IL-10水平較對照組增高(P<0.01),TNF-α、IL-8則較對照組明顯降低(P<0.05).結論 NO能抑製炎癥性細胞因子,促進抗炎細胞因子的活性,故可減輕體外循環併髮癥.
목적 탐토흡입일양화담(NO)대영유인체외순배수술중세포인자변화적영향급의의.방법 실간격결손적영유인30례수궤분위대조조화NO조,NO조재체외순배기간흡인40×10-6NO직지관흉.재체외순배전、주동맥개방후1、3、5、10 min분별취우상폐정맥혈화우심방혈측정TNF-α、IL-8、IL-10.결과 NO조IL-10수평교대조조증고(P<0.01),TNF-α、IL-8칙교대조조명현강저(P<0.05).결론 NO능억제염증성세포인자,촉진항염세포인자적활성,고가감경체외순배병발증.
Objective To investigate the impact of inhahng nitric oxide (NO) on the changes of cytokine during cardiopulmo-nary bypass in infants. Methods Thirty infants with VSD were randomly divided into two groups: NO group and control group. Thepatients of NO group inhaled 40×10-6 NO during CPB. The change of TNF-α, I1-,-8, IL-10 were observed before CPB, at 1, 3, 5,10 min after aortic declamping. Results The values of TNF-α,IL-8 decreased significantly(P<0.05), and the values of IL-10 in-creased(P<0.01)in NO group. Conclusion iNO can inhibit the activation of inflammatory facts (TNF-α, IL-8 ),and promote theactivation of anti-inflammatory facts (IL-10). The use of NO may reduce the complication of CPB can be reduced by clinical means.
