CAJ | 학술논문

目的：探讨急性心肌梗死(AMI)静脉溶栓治疗对校正的QT间期离散度(QTcd)的影响。方法：用体表心电图同步12导联测量64例AMI患者溶栓前及溶栓后3小时的QTcd，并对出现与未出现恶性心律失常者的 QTcd进行比较。设30例正常人做对照组，取其QTcd作为参考值。结果AMI组溶栓前与对照组QTcd差异有显著性(P＜0.01)，溶栓后再通组QTcd时限缩短，而未通组QTcd时限无明显变化，两者的QTcd差异有显著性(P＜ 0.01)。出现恶性心律失常的AMI患者，其QTcd长于不出现者。结论：成功的溶栓治疗可使QTcd缩短，亦可减少恶性心律失常的发生。
목적：탐토급성심기경사(AMI)정맥용전치료대교정적QT간기리산도(QTcd)적영향。방법：용체표 심전도동보12도련측량64례AMI환자용전전급용전후3소시적QTcd，병대출현여미출현악성심률실상자적 QTcd진행비교。설30례정상인주대조조，취기QTcd작위삼고치。결과AMI조용전전여대조조QTcd차이유현 저성(P＜0.01)，용전후재통조QTcd시한축단，이미통조QTcd시한무명현변화，량자적QTcd차이유현저성(P＜ 0.01)。출현악성심률실상적AMI환자，기QTcd장우불출현자。결론：성공적용전치료가사QTcd축단，역가감소 악성심률실상적발생。
Objective: To investigate the effect of intravenous thrombolytic treatment on QT corrected dispersion (QTcd) in acute myocardial infarction (AMI). Methods:QTcd were measured in 64 AMI patients using synchronous 12 lead electrocardio graph pre and 3 hours post intravenous thrombolytic treatment. QTcd were compared in patients with and without fatal ar rhythmia. Thirty healthy persons were in control group. Results: There was a significant difference in QTcd between AMI and control group before treatment (P＜0.01 ). QTcd significantly shortened in reperfusion group after thrombolytic treat ment, and there was no significant change of QTcd in non-perfusion group. There was a significant difference of QTcd be tween this two groups (P＜0.01). QTcd were longer in patients with fatal arrhythmia than that in patients without fatal arrhythmia. Conclusion:Shortened QTcd and low incidence of fatal arrhythmia can be obtained by successful thrombolytic treatment in AMI.