化学研究与应用
化學研究與應用
화학연구여응용
CHEMICAL RESEARCH AND APPLICATION
2008年
6期
667-670
,共4页
王建平%李华民%王灵芝%李英飞%陈庆华
王建平%李華民%王靈芝%李英飛%陳慶華
왕건평%리화민%왕령지%리영비%진경화
不对称合成%5-(L)-孟氧基-4-苄氨基丁烯内酯%晶体结构
不對稱閤成%5-(L)-孟氧基-4-芐氨基丁烯內酯%晶體結構
불대칭합성%5-(L)-맹양기-4-변안기정희내지%정체결구
asymmetric synthesis%5-(L)-menthyloxy-4-benzylamine-butenolide%crystal structure
温和条件下,苄胺与手性合成子5-(L)-孟氧基3-溴-2(5)呋喃酮通过串联的不对称迈克尔加成/分子内消除反应合成了一种新手性化合物:5-L-孟氧基-4-苄胺基丁烯内酯.产物经过IR 、1H-NMR 、MS谱学表征,并经X-ray单晶衍射测定了其结构.新化合物属于正交晶系,P212121 空间群,a=5.2945(4),b=14.2829(10),c=26.0769(18) ,Mr=343.45,Z=4,V=1972.0(2) 3,Dc = 1.157 g/cm3,μ(MoKα)=0.076 mm-1,F(000)=744,R=0.0387 ,wR=0.0880.
溫和條件下,芐胺與手性閤成子5-(L)-孟氧基3-溴-2(5)呋喃酮通過串聯的不對稱邁剋爾加成/分子內消除反應閤成瞭一種新手性化閤物:5-L-孟氧基-4-芐胺基丁烯內酯.產物經過IR 、1H-NMR 、MS譜學錶徵,併經X-ray單晶衍射測定瞭其結構.新化閤物屬于正交晶繫,P212121 空間群,a=5.2945(4),b=14.2829(10),c=26.0769(18) ,Mr=343.45,Z=4,V=1972.0(2) 3,Dc = 1.157 g/cm3,μ(MoKα)=0.076 mm-1,F(000)=744,R=0.0387 ,wR=0.0880.
온화조건하,변알여수성합성자5-(L)-맹양기3-추-2(5)부남동통과천련적불대칭매극이가성/분자내소제반응합성료일충신수성화합물:5-L-맹양기-4-변알기정희내지.산물경과IR 、1H-NMR 、MS보학표정,병경X-ray단정연사측정료기결구.신화합물속우정교정계,P212121 공간군,a=5.2945(4),b=14.2829(10),c=26.0769(18) ,Mr=343.45,Z=4,V=1972.0(2) 3,Dc = 1.157 g/cm3,μ(MoKα)=0.076 mm-1,F(000)=744,R=0.0387 ,wR=0.0880.
The novel chiral 5-(L)-menthyloxy(1R,2S,5R)-4-benzylamine-butenolide (C21H29NO3) is synthesized by Michael addition / internal elimination reaction of 5-(L)-menthyloxy-3- bromo -2(5H)-furanone with benzylamine under mild condition,and its structure is determined by X-ray diffraction. The title chiral compound belongs to orthorhombic,space group P212121 with a=5.2945(4),b=14.2829(10),c=26.0769(18)(A),Mr=343.45,Z=4,V=1972.0(2)(A)3,Dc = 1.157 g/cm3,μ(MoKα)=0.076 mm-1,F(000)=744,R=0.0387 and wR=0.0880.