中国医药工业杂志
中國醫藥工業雜誌
중국의약공업잡지
CHINESE JOURNAL OF PHARMACEUTICALS
2010年
1期
30-31,40
,共3页
尤恒%王洪光%崔鑫萌%孟祥磊
尤恆%王洪光%崔鑫萌%孟祥磊
우항%왕홍광%최흠맹%맹상뢰
流化床%顶喷%包衣效果
流化床%頂噴%包衣效果
류화상%정분%포의효과
fluidized bed%top-spray%coating effect
选择平均粒径为250μm的石英砂作为模型,分别用Eudragit NE30D水分散体与Eudragit RL乙醇溶液包衣,用正交设计考察流化床顶喷过程中各因素对包农效果的影响.结果表明,用Eudragit NE30D水分散体包衣时,包衣液流速和雾化压力对包衣效果影响较大,用Eudragit RL乙醇溶液包衣时则是增塑剂浓度的影响较大.
選擇平均粒徑為250μm的石英砂作為模型,分彆用Eudragit NE30D水分散體與Eudragit RL乙醇溶液包衣,用正交設計攷察流化床頂噴過程中各因素對包農效果的影響.結果錶明,用Eudragit NE30D水分散體包衣時,包衣液流速和霧化壓力對包衣效果影響較大,用Eudragit RL乙醇溶液包衣時則是增塑劑濃度的影響較大.
선택평균립경위250μm적석영사작위모형,분별용Eudragit NE30D수분산체여Eudragit RL을순용액포의,용정교설계고찰류화상정분과정중각인소대포농효과적영향.결과표명,용Eudragit NE30D수분산체포의시,포의액류속화무화압력대포의효과영향교대,용Eudragit RL을순용액포의시칙시증소제농도적영향교대.
With quartz sand(250 μm)as model and Eudragit NE30D aqueous dispersion or Eudragit RL ethanol solution as coating material,the influence factors on coating effect in top-spray fluidized bed coating process were investigated by orthogonal design.The results showed that the flow rate of coating solution and atomization pressure significantly affected coating effect with Eudragit NE30D aqueous dispersion,while the concentration of plasticizer had a greater effect with Eudragit RL ethanol solution.
