CAJ | 학술논문

丝聚蛋白在表皮含量丰富,主要存在于表皮的最外层,对表皮的屏障功能起着重要的作用.近年的研究发现,寻常性鱼鳞病及特应性皮炎的发病与丝聚蛋白的编码基因Flg有明显的相关性.Flg失功能突变使表皮丝聚蛋白表达减少或缺如,导致表皮的屏障功能受损,使环境中的变应原、刺激物等易于进入表皮,继而引起各种病理生理变化.
사취단백재표피함량봉부,주요존재우표피적최외층,대표피적병장공능기착중요적작용.근년적연구발현,심상성어린병급특응성피염적발병여사취단백적편마기인Flg유명현적상관성.Flg실공능돌변사표피사취단백표체감소혹결여,도치표피적병장공능수손,사배경중적변응원、자격물등역우진입표피,계이인기각충병리생리변화.
Filaggrin, which is abundant in epidermis and mainly localized in the outer layer of epidermis, plays an important role in the barrier function of epidermis. It has been evidenced that the development of ichthyosis vulgaris and atopic dermatitis is associated with the coding genes of filaggrin. The loss-of-function mutations in filaggrin gene may lead to the absence or decreased expression of epidermal filaggrin, barrier function damage, easier entry of environmental antigens and stimuli into epidermis followed by various pathophysilogical changes.