CAJ | 학술논문

目的观察和评价罗红霉素缓释胶囊联合其它抗结核药物治疗耐多药肺结核病( MDR-PTB)的疗效.方法选择我院住院的MDR-PTB患者120例做为研究对象,将其随机分为治疗组60例和对照组60例；对照组采用司帕沙星、丁氨卡那霉素及其他三种抗结核药物作为抗痨方案,治疗组在对照组基础上添加罗红霉素缓释胶囊,疗程12个月；观察两组转阴率和疗效.结果第3个月末,治疗组痰菌转阴率为64％,对照组为42％,两组对比差异有统计学意义(x2=5.52,P＜0.05).疗程结束时,治疗组痰菌转阴率为91％,对照组为72％,两组比较差异有统计学意义(x2=6.62,P＜0.01)；治疗组病灶吸收显效率为89％,对照组为70％,两组对比差异有统计学意义(x2=6.14,P＜0.05).结论罗红霉素缓释胶囊联合其它抗结核药物治疗MDR-PTB疗效肯定,对促进痰菌阴转、病灶吸收、空洞闭合有显著作用.
목적 관찰화평개라홍매소완석효낭연합기타항결핵약물치료내다약폐결핵병( MDR-PTB)적료효.방법 선택아원주원적MDR-PTB환자120례주위연구대상,장기수궤분위치료조60례화대조조60례；대조조채용사파사성、정안잡나매소급기타삼충항결핵약물작위항로방안,치료조재대조조기출상첨가라홍매소완석효낭,료정12개월；관찰량조전음솔화료효.결과 제3개월말,치료조담균전음솔위64％,대조조위42％,량조대비차이유통계학의의(x2=5.52,P＜0.05).료정결속시,치료조담균전음솔위91％,대조조위72％,량조비교차이유통계학의의(x2=6.62,P＜0.01)；치료조병조흡수현효솔위89％,대조조위70％,량조대비차이유통계학의의(x2=6.14,P＜0.05).결론 라홍매소완석효낭연합기타항결핵약물치료MDR-PTB료효긍정,대촉진담균음전、병조흡수、공동폐합유현저작용.
Objective To observe and assess the efficacy of roxithromycin sustained-release capsules com-bined with other anti-tuberculosis drugs in the treatment of multidrug-resistant pulmonary tuberculosis ( MDR-PTB ).Methods 120 patients with MDR-PTB were selected as the subjecs of this study and then were randomly divided intostudy group and control group,60 for each group.The control group received sparfloxacin,amikacin,and other three kindsof anti-tuberculosis drugs as anti-tuberculosis scheme,and the study group received roxithromycin for 12 months inaddition to the therapies used in the control group.Results At the end of the third month,the sputum negative conversionrate was 64％ in the study group and 42％ in the control group,with a statistical significance ( ~=5.52,P＜ 0.05 ).Atthe end of treatment,the sputum negative conversion rate was 91％ in the study group and 72％ in the control group,witha significant difference ( x2=6.62,P＜ 0.01 ).The rate of lesion absorption was 89％ in the study group and 70％ in thecontrol group,with a statistical significance ( x2=6.14,P ＜ 0.05 ).Conclusions Roxithromycin sustained-releasecapsules combined with other anti-tuberculosis drugs is efficacious in the treatment of MDR-PTB and plays a role inpromoting sputum negative conversion,lesion absorption,and cavity closure.