中华临床营养杂志
中華臨床營養雜誌
중화림상영양잡지
CHINESE JOURNAL OF CLINICAL NUTRITION
2010年
5期
292-298
,共7页
饮食%C反应蛋白%2型糖尿病%动脉粥样硬化
飲食%C反應蛋白%2型糖尿病%動脈粥樣硬化
음식%C반응단백%2형당뇨병%동맥죽양경화
Diet%C-reactive protein%Type 2 diabetes mellitus%Atherosclerosis
目的 比较2型糖尿病颈动脉内膜增厚与未增厚患者的营养摄入特点及C反应蛋白(CRP)水平差异,分析饮食、CRP与颈动脉内膜厚度的关系.方法 2007年2月至9月在广州市第一医院门诊或住院治疗的2型糖尿病患者60例,平均年龄(59.5±7.27)岁,根据颈动脉内膜是否增厚分为两组(n=30),进行膳食调查、人体测量,检测血高敏CRP、尿微量白蛋白、血糖、C肽、血脂、糖化血红蛋白、肾功能等指标,并比较两组结果.结果 2型糖尿病颈动脉内膜未增厚组的日均蔬菜类、水果类、水产类和维生素C摄入量均明显高于颈动脉内膜增厚组(P＜0.05),颈动脉内膜增厚组的高敏CRP明显高于2型糖尿病颈动脉内膜未增厚组(P=0.000),两组其余实验室指标的差异均无统计学意义.2型糖尿病患者高敏CRP与颈动脉内膜厚度呈正相关(r=0.36,P=0.004);血清CRP水平与蔬菜水果的摄入量呈负相关(r=-0.334,P=0.01),与水产类的摄入量呈负相关(r=-0.315,P=0.016),与膳食维生素C的摄入量呈负相关(r=-0.2786,P=0.038);水果摄入量与内膜厚度呈负相关(r=-0.33,P=0.01).结论 膳食中蔬果类、水产类食物、维生素C可能是2型糖尿病动脉粥样硬化的保护因子,增加摄入可能有利于糖尿病患者预防动脉粥样硬化,CRP与2型糖尿病动脉粥样硬化的发生发展相关联.
目的 比較2型糖尿病頸動脈內膜增厚與未增厚患者的營養攝入特點及C反應蛋白(CRP)水平差異,分析飲食、CRP與頸動脈內膜厚度的關繫.方法 2007年2月至9月在廣州市第一醫院門診或住院治療的2型糖尿病患者60例,平均年齡(59.5±7.27)歲,根據頸動脈內膜是否增厚分為兩組(n=30),進行膳食調查、人體測量,檢測血高敏CRP、尿微量白蛋白、血糖、C肽、血脂、糖化血紅蛋白、腎功能等指標,併比較兩組結果.結果 2型糖尿病頸動脈內膜未增厚組的日均蔬菜類、水果類、水產類和維生素C攝入量均明顯高于頸動脈內膜增厚組(P＜0.05),頸動脈內膜增厚組的高敏CRP明顯高于2型糖尿病頸動脈內膜未增厚組(P=0.000),兩組其餘實驗室指標的差異均無統計學意義.2型糖尿病患者高敏CRP與頸動脈內膜厚度呈正相關(r=0.36,P=0.004);血清CRP水平與蔬菜水果的攝入量呈負相關(r=-0.334,P=0.01),與水產類的攝入量呈負相關(r=-0.315,P=0.016),與膳食維生素C的攝入量呈負相關(r=-0.2786,P=0.038);水果攝入量與內膜厚度呈負相關(r=-0.33,P=0.01).結論 膳食中蔬果類、水產類食物、維生素C可能是2型糖尿病動脈粥樣硬化的保護因子,增加攝入可能有利于糖尿病患者預防動脈粥樣硬化,CRP與2型糖尿病動脈粥樣硬化的髮生髮展相關聯.
목적 비교2형당뇨병경동맥내막증후여미증후환자적영양섭입특점급C반응단백(CRP)수평차이,분석음식、CRP여경동맥내막후도적관계.방법 2007년2월지9월재엄주시제일의원문진혹주원치료적2형당뇨병환자60례,평균년령(59.5±7.27)세,근거경동맥내막시부증후분위량조(n=30),진행선식조사、인체측량,검측혈고민CRP、뇨미량백단백、혈당、C태、혈지、당화혈홍단백、신공능등지표,병비교량조결과.결과 2형당뇨병경동맥내막미증후조적일균소채류、수과류、수산류화유생소C섭입량균명현고우경동맥내막증후조(P＜0.05),경동맥내막증후조적고민CRP명현고우2형당뇨병경동맥내막미증후조(P=0.000),량조기여실험실지표적차이균무통계학의의.2형당뇨병환자고민CRP여경동맥내막후도정정상관(r=0.36,P=0.004);혈청CRP수평여소채수과적섭입량정부상관(r=-0.334,P=0.01),여수산류적섭입량정부상관(r=-0.315,P=0.016),여선식유생소C적섭입량정부상관(r=-0.2786,P=0.038);수과섭입량여내막후도정부상관(r=-0.33,P=0.01).결론 선식중소과류、수산류식물、유생소C가능시2형당뇨병동맥죽양경화적보호인자,증가섭입가능유리우당뇨병환자예방동맥죽양경화,CRP여2형당뇨병동맥죽양경화적발생발전상관련.
Objective To compare the characteristics of food and nutrition intake in type 2 diabetes mellitus (T2DM) patients with or without carotid atherosclerosis and analyze the relationship between diets/C-reactive protein (CRP) and carotid intima-media thickness (C-IMT). Methods Sixty patients with T2DM were enrolled and divided into two groups based on C-IMT: group A (C-IMT ＜ 1 mm, n=30) and group B (C-IMT≥1 mm, n=30). All subjects were investigated with questionnaires including 3-day food recall They all took somatometric measurement. Blood and urine samples were collected in all subjects to examine the levels of high sensitive-CRP,C-peptide, blood glucose, glycosylated hemoglobin, blood lipid, renal function, urine microalbumin, and other indicators. Results The intakes of vegetables, fruits, and aquatic products were significantly higher in group A than in group B ( P ＜ 0. 05 ). The intake of vitamin C in group A was significantly higher than that in group B ( P ＜0. 05 ). The levels of CRP in group B was significant higher than that in group A (P = 0. 000). Positive correlation was found between CRP level and C-IMT in T2DM patients ( r = 0. 36, P = 0. 004). Furthermore, CRP was negatively correlated with the intakes of vegetables and fruits ( r = - 0. 334, P = 0. 01 ), aquatic products ( r = -0. 315, P = 0. 016), and vitamin C ( r = - 0. 2786, P = 0. 038 ), respectively. The intake of fruits was negatively correlated with C-IMT (r, = -0. 33, P = 0. 01 ). Conclusions T2DM patients without carotid atherosclerosis intake more vegetables, fruits, aquatic products and vitamin C than those with atherosclerosis. Vegetables, fruits,sea foods and vitamin C may be the protective factors against atherosclerosis in T2DM patients. CRP is associated with the development of atherosclerosis in T2DM patients.
