中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
4期
311-313
,共3页
王忠莉%夏冰%王桦%胡正国%陈青松%程金童%文斌
王忠莉%夏冰%王樺%鬍正國%陳青鬆%程金童%文斌
왕충리%하빙%왕화%호정국%진청송%정금동%문빈
非酒精性脂肪肝%高血压%脂联素%胰岛素抵抗
非酒精性脂肪肝%高血壓%脂聯素%胰島素牴抗
비주정성지방간%고혈압%지련소%이도소저항
Non-alcoholic fatty liver disease%Essential hypertension%Adiponectin%Insulin resistance
目的 研究非酒精性脂肪肝(NAFLD)合并高血压患者血清脂联素水平与胰岛素抵抗(HO-MA)程度的相关性.方法 性别匹配的NAFLD合并高血压患者65例,单纯NAFLD患者51例,健康体检者54例作为对照组.测定体质指数(BMI),检测空腹血糖(FBS)、丙氨酸氨基转移酶(ALT)、胆固醇、甘油三酯(TG)等生化指标并行肝脏B超检查.放射免疫法测定空腹胰岛素(FINS)水平,计算胰岛素抵抗指数(HO-MA-IR).同时酶联免疫法测定血清脂联素水平.并用相关及多元回归分析血清脂联素水平与各参数的相关性.结果 NAFLD患者BMI[(27.12±2.63)kg/m2]、ALT[(35.86±20.16)U/L]、TG[(2.73±1.43)mmol/L]、FBS[(5.71±0.65)mmol/L]、FINS[(12.33±4.16)mIU/L]、HOMA-m(3.11±1.04)]水平较对照组高[(23.14±2.86)kg/m2、(19.72±8.90)U/L、(1.35±0.59)mmol/L、(5.19±0.78)mmol/L、(2.31±1.61)mIU/L、0.53±0.39]P＜0.05),脂联素水平较对照组低([(4.52±2.05)、(8.88±3.37)μg/ml]P＜0.05);NAFLD 合并高血压患者HOMA-IR较单纯NAFLD患者更高(4.47±2.87、3.11±1.04,P＜0.05),脂联素水平更低((3.19±1.52)、(4.52±2.05)μg/ml,P＜0.05).结论 NAFLD合并高血压患者HOMA-IR、FINS较NAFLD更为严重,脂联素水平更低.脂联素与BMI、ALT、FBS、FINS、TG、HOMA呈负相关,与性别相关,与年龄、胆固醇相关不明显.脂联素与TG以及HOMA相关.
目的 研究非酒精性脂肪肝(NAFLD)閤併高血壓患者血清脂聯素水平與胰島素牴抗(HO-MA)程度的相關性.方法 性彆匹配的NAFLD閤併高血壓患者65例,單純NAFLD患者51例,健康體檢者54例作為對照組.測定體質指數(BMI),檢測空腹血糖(FBS)、丙氨痠氨基轉移酶(ALT)、膽固醇、甘油三酯(TG)等生化指標併行肝髒B超檢查.放射免疫法測定空腹胰島素(FINS)水平,計算胰島素牴抗指數(HO-MA-IR).同時酶聯免疫法測定血清脂聯素水平.併用相關及多元迴歸分析血清脂聯素水平與各參數的相關性.結果 NAFLD患者BMI[(27.12±2.63)kg/m2]、ALT[(35.86±20.16)U/L]、TG[(2.73±1.43)mmol/L]、FBS[(5.71±0.65)mmol/L]、FINS[(12.33±4.16)mIU/L]、HOMA-m(3.11±1.04)]水平較對照組高[(23.14±2.86)kg/m2、(19.72±8.90)U/L、(1.35±0.59)mmol/L、(5.19±0.78)mmol/L、(2.31±1.61)mIU/L、0.53±0.39]P＜0.05),脂聯素水平較對照組低([(4.52±2.05)、(8.88±3.37)μg/ml]P＜0.05);NAFLD 閤併高血壓患者HOMA-IR較單純NAFLD患者更高(4.47±2.87、3.11±1.04,P＜0.05),脂聯素水平更低((3.19±1.52)、(4.52±2.05)μg/ml,P＜0.05).結論 NAFLD閤併高血壓患者HOMA-IR、FINS較NAFLD更為嚴重,脂聯素水平更低.脂聯素與BMI、ALT、FBS、FINS、TG、HOMA呈負相關,與性彆相關,與年齡、膽固醇相關不明顯.脂聯素與TG以及HOMA相關.
목적 연구비주정성지방간(NAFLD)합병고혈압환자혈청지련소수평여이도소저항(HO-MA)정도적상관성.방법 성별필배적NAFLD합병고혈압환자65례,단순NAFLD환자51례,건강체검자54례작위대조조.측정체질지수(BMI),검측공복혈당(FBS)、병안산안기전이매(ALT)、담고순、감유삼지(TG)등생화지표병행간장B초검사.방사면역법측정공복이도소(FINS)수평,계산이도소저항지수(HO-MA-IR).동시매련면역법측정혈청지련소수평.병용상관급다원회귀분석혈청지련소수평여각삼수적상관성.결과 NAFLD환자BMI[(27.12±2.63)kg/m2]、ALT[(35.86±20.16)U/L]、TG[(2.73±1.43)mmol/L]、FBS[(5.71±0.65)mmol/L]、FINS[(12.33±4.16)mIU/L]、HOMA-m(3.11±1.04)]수평교대조조고[(23.14±2.86)kg/m2、(19.72±8.90)U/L、(1.35±0.59)mmol/L、(5.19±0.78)mmol/L、(2.31±1.61)mIU/L、0.53±0.39]P＜0.05),지련소수평교대조조저([(4.52±2.05)、(8.88±3.37)μg/ml]P＜0.05);NAFLD 합병고혈압환자HOMA-IR교단순NAFLD환자경고(4.47±2.87、3.11±1.04,P＜0.05),지련소수평경저((3.19±1.52)、(4.52±2.05)μg/ml,P＜0.05).결론 NAFLD합병고혈압환자HOMA-IR、FINS교NAFLD경위엄중,지련소수평경저.지련소여BMI、ALT、FBS、FINS、TG、HOMA정부상관,여성별상관,여년령、담고순상관불명현.지련소여TG이급HOMA상관.
Objective To explore the relationship of serum adiponectin concentration in patients of non-alcoholic fatty liver disease(NAFLD}with essential hypertension(EH)with insulin resistance.Methods 65 NAFLD patients with EH,51 patients with NAFLD,54 healthy controls were studied.Abdominal ultrasound was taken for fatty liver examination.Serum adiponectin and insulin levels were determined by enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (PIA).Insulin resistance indexes were assessed.Other anthropometric and biochemical variables(including BMI,FBS,ALT,TC and TG)were measured by routine methods.Results The body mass index(BMI)-serum total triglycerin(TG),fasting blood Sugar(FBS),aspartate transaminase(ALT)level,fasting insulin(FINS)and HOMA were significanfly increased(P＜0.05),serum adiponectin was significantly decreasde in NAFLD compared with healthy controls(P＜0.05).Besides,compared with NAFLD,HOMA was significantly increased(P＜0.05)and serum adiponectin wag significantly decreased in NAFLD with EH(P＜0.05).Conclusion compared with NAFLD,NAFLD with EH has further extent of insulin resistance and lower hypoadiponectinemia.Adiponectin is negatively correlated with BMI,ALT,FBS,FINS,TG and HOMA,but not sisnificantly related to age and cholesterol.TG and HOMA are related to adiponectin.
