CAJ | 학술논문

目的探讨G-CSF联合自体骨髓间充质干细胞移植治疗脑梗死的临床效果.方法将42例急性脑梗死患者,随机分为2组:治疗组20例,时照组22例.治疗组给予G-CSF联合骨髓间充质干细胞移植治疗,对照组常规药物治疗.分别于发病时、治疗后三个月评价患者影像学(头MRI弥散像及灌注成像)及神经功能(用美国国立卫生研究院神经功能缺损评分NHISS和BI)变化.结果治疗3个月后,NIHSS积分与BI积分治疗组为4.8±2.0与78.5±7.2,对照组7.2±2.4与56.1±6.3,治疗组均优于对照组(P＜0.01).治疗组头MRI灌注量亦优于对照组.治疗组未见明显不良反应.结论 G-CSF与MSC联合是一种安全有效的方法 ,其疗效也优于传统治疗.
목적 탐토G-CSF연합자체골수간충질간세포이식치료뇌경사적림상효과.방법 장42례급성뇌경사환자,수궤분위2조:치료조20례,시조조22례.치료조급여G-CSF연합골수간충질간세포이식치료,대조조상규약물치료.분별우발병시、치료후삼개월평개환자영상학(두MRI미산상급관주성상)급신경공능(용미국국립위생연구원신경공능결손평분NHISS화BI)변화.결과 치료3개월후,NIHSS적분여BI적분치료조위4.8±2.0여78.5±7.2,대조조7.2±2.4여56.1±6.3,치료조균우우대조조(P＜0.01).치료조두MRI관주량역우우대조조.치료조미견명현불량반응.결론 G-CSF여MSC연합시일충안전유효적방법 ,기료효야우우전통치료.
Objective To investigate the clinical effect of rhG-CSF combined transplantation of autologous bone marrow mesenchymal stem cells on cerebral infarction. Methods 42 acute cerebral infarction patients were randomly divided into tow groups: Injection rhGCSF combined autologous bone marrow mesenchymal stem cells group(treatment group, n=20)and conventionality therapy group(control group, n=22).The efficacy was assessed by National Institutes of Health Stroke Scale(NIHSS), Barthel Index(BI)and diffusion-weighted imaging(DWI),perfusion-weighted imaging(PWI)at baseline and the 3rd month after treatment. Result The scores of NHISS and BI treatment group were 4.8±2.0 and 78.5±7.2 respectively. while were 7.2±2.4 and 56.1±6.3 in control group at the 3rd month after treatment. The difference were significant(P＜0.01).PWI in treatment group Was higher than that in control group. There was no significant side-effect in treatment group. Conclusion rHG-CSF combined autologous bone marrow mesenchymal stem cells is a safe, efficient treatment for acute cerebral infarction patients, which is a better way than conventionality therapy.