CAJ | 학술논문

目的对1例原位肝、异位胰腺I期联合移植进行总结.方法对1例终末期肝病合并2型糖尿病的患者施行肝、胰I期联合移植,肝脏为原位移植,胰腺异位移植于右侧髂窝,胰液空肠引流.术后采用他克莫司、霉酚酸酯及糖皮质激素预防排斥反应,并辅以两剂达利珠单抗.结果术后移植胰腺功能良好,第2天即停用胰岛素.术后14 d,移植肝出现轻度急性排斥反应,调整他克莫司的用量后逆转.受者已存活15个月,移植肝脏及胰腺功能均正常.结论肝、胰联合移植是治疗终末期肝病合并糖尿病的有效方法.
목적 대1례원위간、이위이선I기연합이식진행총결.방법 대1례종말기간병합병2형당뇨병적환자시행간、이I기연합이식,간장위원위이식,이선이위이식우우측가와,이액공장인류.술후채용타극막사、매분산지급당피질격소예방배척반응,병보이량제체리주단항.결과 술후이식이선공능량호,제2천즉정용이도소.술후14 d,이식간출현경도급성배척반응,조정타극막사적용량후역전.수자이존활15개월,이식간장급이선공능균정상.결론 간、이연합이식시치료종말기간병합병당뇨병적유효방법.
Objective To summarize a case of simultaneous orthotopic liver and heterotopic Pancrefls-duodenum transplantation.Methods One patient with end-stage liver disease and type 2 diabetes mellitus received simultaneous liver-pancreas-duodenum transplantation.liver transplantation was performed orthotopically,while pancrease was transplanted to right iliac fossa with enteric drainage of the exocrine secretions.FK506,mycophenolate mofetil(MMF),steroid and two doses of daclizumab were given tO prevent rejection.Results The function of pancreas allograft was recovered immediately and the patient became insulin independence on day 2 postoperation.The liver allograft had an acute rejection episode on day 14 after operation and reversed by adjusting FK506 dose.The recipient was currently liver disease free and insulin free more than 15 months.Conclusion The simultaneous liverpancreas-duodenum transplantation is an effective method in the treatment of end-stage liver disease with diabetes mellitus.