CAJ | 학술논문

目的探讨口内戴用镍铬合金烤瓷冠是否导致机体免疫功能学指标改变.方法对镍铬合金烤瓷冠戴用者795例和对照组198人进行问卷调查、测定尿镍铬和血免疫功能指标,并分析镍铬烤瓷冠戴用时间、尿镍铬与免疫功能指标间的关系.结果将镍铬合金烤瓷冠戴用者和对照组的所有样本合并,根据尿镍和尿铬水平分为尿镍低水平组(＜ 37.28 μg/mol肌酐)、中水平组(37.28～ 115.73 μg/mol肌酐)和高水平组(＞115.73 μg/mol肌酐)；尿铬低水平组(＜34.72 μg/mol肌酐)、中水平组(34.72 ～79.81 μg/mol肌酐)和高水平组(＞79.81 μg/mol肌酐).结果仅发现尿镍高水平组的血清白细胞介素( interleukin,IL)1β水平[(1.50±0.84) μg/L]显著低于尿镍低水平组[(1.63±0.82)μg/L](P＜0.05),未发现尿镍中水平组与低水平组间、尿铬各水平组间在血清肿瘤坏死因子α(tumor necrosis factor-alpha,TNF-α)、IL-1β和IL-6间的差异有统计学意义.单因素方差分析和各影响因素的线性回归分析仅发现年龄与TNF-α的升高有关,未发现戴用时间、数量和金属裸露水平,以及尿镍和尿铬对TNF-α、IL-1β和IL-6等免疫学指标的显著影响.结论本研究未观察到戴用镍铬合金烤瓷冠与机体免疫功能指标TNF-α、IL-1β和IL-6的升高具有相关关系.
목적 탐토구내대용얼락합금고자관시부도치궤체면역공능학지표개변.방법 대얼락합금고자관대용자795례화대조조198인진행문권조사、측정뇨얼락화혈면역공능지표,병분석얼락고자관대용시간、뇨얼락여면역공능지표간적관계.결과 장얼락합금고자관대용자화대조조적소유양본합병,근거뇨얼화뇨락수평분위뇨얼저수평조(＜ 37.28 μg/mol기항)、중수평조(37.28～ 115.73 μg/mol기항)화고수평조(＞115.73 μg/mol기항)；뇨락저수평조(＜34.72 μg/mol기항)、중수평조(34.72 ～79.81 μg/mol기항)화고수평조(＞79.81 μg/mol기항).결과 부발현뇨얼고수평조적혈청백세포개소( interleukin,IL)1β수평[(1.50±0.84) μg/L]현저저우뇨얼저수평조[(1.63±0.82)μg/L](P＜0.05),미발현뇨얼중수평조여저수평조간、뇨락각수평조간재혈청종류배사인자α(tumor necrosis factor-alpha,TNF-α)、IL-1β화IL-6간적차이유통계학의의.단인소방차분석화각영향인소적선성회귀분석부발현년령여TNF-α적승고유관,미발현대용시간、수량화금속라로수평,이급뇨얼화뇨락대TNF-α、IL-1β화IL-6등면역학지표적현저영향.결론 본연구미관찰 도대용얼락합금고자관여궤체면역공능지표TNF-α、IL-1β화IL-6적승고구유상관관계.
Objective To investigate the immunological function parameters in patients undergoing dental restoration of nickel-chromium (Ni-Cr).Methods Seven hundred and ninety-five Ni-Cr alloy consumers as exposure group,together with 198 controls,were surveyed by the questionnaire and the biological examination of immunological function.Results After splitting all subjects into three groups of equal sample size by urinary Ni or urinary Cr,serum interleukin-1 beta( IL-1 β) was found to be significantly higher in the group of urinary Ni ＞ 115.73 μg/mol creatinine comparing to the group of urinary Ni ＜ 37.28 μg/mol creatinine (P ＜ 0.05 ).No changes of immunological parameters in surm [ tumor necrosis factoralpha (TNF-α),IL-1β,and IL-6 ] were found in other groups of urinary Ni or Cr.Both one way analysis of variance (ANOVA) and linear regression analysis did not find any association between serum changes of immunological parameters and the parameters of alloy restoration (period,number and the level of metal crown uncovered with porcelain).Conclusions This study did not show positive associations between dental restoration of Ni-Cr alloy and serum levels of TNF-α,IL-1 β and IL-6.